In vitro Antibacterial Potential of the Oleoresin, Leaf Crude Hydroalcoholic Extracts and Isolated Compounds of the Copaifera spp. Against Helicobacter pylori

Author(s)

Moraes, Thais da Silva ; Lima, Lucas Kozoski ; Veneziani, Rodrigo Cassio Sola ; Ambrosio, Sergio Ricardo ; dos Santos, Raquel Alves ; da Silva, Jonas Joaquim Mangabeira ; Ribeiro, Gustavo Lima ; Bastos, Jairo Kenupp ; Martins, Carlos Henrique Gomes

• Document type: Journal article
• Source: JOURNAL OF BIOLOGICALLY ACTIVE PRODUCTS FROM NATURE; v. 11, n. 2, p. 7-pg., 2021-03-04.

Abstract

Helicobacter pylori is often related to severe clinical manifestations of infections and may increase an individual's chance of developing stomach cancer. We are reporting the in vitro anti-H. pylori effects of several Copaifera spp. derivatives such as oleoresins, hydroalcoholic crude extracts from the leaves, and isolated compounds, by determining their Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values. It was obtained promising MIC (MBC) values, ranging from 6.25 (12.5) to 100 (400) mu g/mL, from 12.5 (25) to 100 (100) mu g/mL, and from 3.12 (3.12) to 100 (100) mu g/mL respectively, for Copaifera spp. oleoresins, leave crude hydroalcoholic extracts and isolated compounds. Therefore, all Copaifera spp. derivatives displayed promising antibacterial activities against H. pylori. (AU)

• FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/19714-9 - A preliminary investigation of the anti-Helicobacter pylori by some Copaifera spp. species
• Grantee: Lucas Kozoski de Lima
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/25237-0 - Kaurane-type diterpenes: activity against anaerobic bacteria and proteomics
• Grantee: Carlos Henrique Gomes Martins
• Support Opportunities: Regular Research Grants