Beneficial Short-Term Effects of Bariatric Surgery on Nutritional Inflammatory Profile and Metabolic Biomarkers

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Seva, Danielle Cristina ; Monico-Neto, Marcos ; Antunes, Hanna Karen Moreira ; Pino, Jessica Monteiro Volejnik ; Bittencourt, Lia Rita Azeredo ; Galvao, Thales Delmondes ; Damaso, Ana R. ; Oyama, Lila Missae ; Shivappa, Nitin ; Hebert, James R. ; Tufik, Sergio ; Campos, Raquel Munhoz da Silveira

• Document type: Journal article
• Source: OBESITY SURGERY; v. 33, n. 9, p. 10-pg., 2023-08-04.

Abstract

Purpose Bariatric surgery (BS) has several potential metabolic benefits. However, little is known about its impact on changes in the inflammatory potential of diet and its effect on inflammatory and metabolic markers. This study aimed to assess the short-term beneficial effects of BS on dietary inflammatory potential and inflammatory and metabolic markers. Materials and Methods Participants (n = 20) were evaluated 3 months before and after BS. Body mass, body mass index, anthropometric measurements, fat mass, fat-free mass, visceral fat, skeletal muscle mass, basal metabolic rate, serum lipids, HOMA-IR, QUICKI and inflammatory markers, including leptin, adiponectin, adiponectin/leptin ratio and plasminogen activator inhibitor-1 (PAI-1), were evaluated. Diet data were collected using a 3-day diet record and the dietary inflammatory index (DII (R)) and energy-adjusted dietary inflammatory index (E-DIITM) scores were computed. Results There was a reduction in DII (R) (2.56 vs 2.13) and E-DIITM (2.18 vs 0.45) indicating an improvement in inflammatory nutritional profile. Moreover, there were increases in the adiponectin/leptin ratio (0.08 vs 0.21) and QUICKI scores (0.31 vs 0.37), and reductions in leptin (36.66 vs 11.41 ng/ml) and HOMA-IR scores (3.93 vs 1.50). There were also improvements in body composition and anthropometric parameters. Conclusions BS promotes changes in metabolic profile, inflammatory state and food intake and these modifications appeared to be associated with improvements in diet- related inflammation, an increase in the adiponectin/leptin ratio and a reduction in leptin. These results contribute to knowledge on the contribution bariatric surgery can make to the treatment of obesity and the reduction of related comorbidities. (AU)

• FAPESP's process: 18/15921-8 - Evaluation of autophagic flow in response to cellular stress of musculoskeletal and adipose tissues in obese patients with obstructive sleep apnea
• Grantee: Marcos Mônico Neto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral