Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells

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Dourado, Douglas ; Batista, Fabiana Pacheco Reis ; Philadelpho, Biane Oliveira ; de Souza, Myla Lobo ; de Cerqueira e Silva, Mariana Barros ; de Grandis, Rone Aparecido ; Miranda, Priscila Anjos ; Colauto, Nelson Barros ; Pereira, Daniel T. T. ; Formiga, Fabio Rocha ; Cilli, Eduardo Maffud ; Pavan, Fernando Rogerio ; de Souza, Carolina Oliveira ; Ferreira, Ederlan de Souza

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 15, p. 15-pg., 2023-08-01.

Abstract

This study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 & PLUSMN; 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 & mu;g/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 & mu;g/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 & mu;g/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma. (AU)

• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants