| Full text | |
| Author(s): |
Sigrist, Renata
;
da Costa, Bruna Zucoloto
;
Marsaioli, Anita Jocelyne
;
de Oliveira, Luciana Gonzaga
Total Authors: 4
|
| Document type: | Journal article |
| Source: | BIOTECHNOLOGY ADVANCES; v. 33, n. 5, p. 18-pg., 2015-09-01. |
| Abstract | |
Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases. (C) 2015 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 11/10378-5 - Purification and functional characterization of copper mine microbial oxidoreductases enzymes |
| Grantee: | Bruna Zucoloto da Costa |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp. |
| Grantee: | Renata Sigrist |
| Support Opportunities: | Scholarships in Brazil - Master |