Strategic use of organoids and organs-on-chip as biomimetic tools

Author(s):Show less -

Santos, Anderson K. ; Scalzo, Sergio ; de Souza, Raysa T. V. ; Santana, Pedro H. G. ; Marques, Bruno L. ; Oliveira, Lucas F. ; Filho Daniel, M. ; Kihara, Alexandre Hiroaki ; Santiago, Helton da Costa ; Parreira, Ricardo C. ; Birbrair, Alexander ; Ulrich, Henning ; Resende, Rodrigo R.

• Document type: Journal article
• Source: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; v. 144, p. 8-pg., 2023-03-17.

Abstract

Organoid development and organ-on-a-chip are technologies based on differentiating stem cells, forming 3D multicellular structures resembling organs and tissues in vivo. Hence, both can be strategically used for disease modeling, drug screening, and host-pathogen studies. In this context, this review highlights the significant ad-vancements in the area, providing technical approaches to organoids and organ-on-a-chip that best imitate in vivo physiology. (AU)

• FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
• Grantee: Alexander Henning Ulrich
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/11667-0 - Cellular and electrophysiological changes in the hippocampus caused by neurodegenerative processes related to neonatal anoxia and temporal lobe epilepsy
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
• Grantee: Alexander Henning Ulrich
• Support Opportunities: Research Projects - Thematic Grants