Evidence of disturbed insulin signaling in animal models of Alzheimer's disease

Author(s)

Alves, Suelen Santos ; Servilha-Menezes, Gabriel ; Rossi, Leticia ; da Silva Junior, Rui Milton Patricio ; Garcia-Cairasco, Norberto

• Document type: Journal article
• Source: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 152, p. 23-pg., 2023-09-01.

Abstract

Since glucose reuptake by neurons is mostly independent of insulin, it has been an intriguing question whether insulin has or not any roles in the brain. Consequently, the identification of insulin receptors in the central nervous system has fueled investigations of insulin functions in the brain. It is also already known that insulin can influence glucose reuptake by neurons, mostly during activities that have the highest energy demand. The identification of high density of insulin receptors in the hippocampus also suggests that insulin may present important roles related to memory. In this context, studies have reported worse performance in cognitive tests among diabetic patients. In addition, alterations in the regulation of central insulin pathways have been observed in the brains of Alzheimer's disease (AD) patients. In fact, some authors have proposed AD as a third type of diabetes and recently, our group proposed insulin resistance as a common link between different AD hypotheses. Therefore, in the present narrative review, we intend to revise and gather the evidence of disturbed insulin signaling in experimental animal models of AD. (AU)

• FAPESP's process: 21/14907-4 - Effects of moderate alcohol consumption on Alzheimer's Disease related to central insulin resistance
• Grantee: Leticia Rossi
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 14/50891-1 - INCT 2014: Translational Medicine
• Grantee: Jaime Eduardo Cecilio Hallak
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/21155-3 - Wistar audiogenic rat (WAR): a possible model for the study of Alzheimer's Disease related to insulin resistance
• Grantee: Suélen Santos Alves
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/02787-4 - Effects of cannabidiol vehiculated in nanoemulsion in rats submitted to the chemical model of temporal lobe epilepsy
• Grantee: Gabriel Servilha Menezes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/00849-2 - Uncovering pathophysiological and molecular mechanisms involved in tumorigenesis by platforms for next-generation sequencing (NGS)
• Grantee: Rui Milton Patrício da Silva Junior
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/05957-8 - Epilepsies and neuropsyquiatric comorbidities: characterization of the effects of the treatment with cannabidiol and HUF-101 in in vivo and in vitro experimental models
• Grantee: Norberto Garcia Cairasco
• Support Opportunities: Regular Research Grants