INCT 2014: Translational Medicine

• Grant number: 14/50891-1
• Support type: Research Projects - Thematic Grants
• Duration: July 01, 2017 - June 30, 2023
• Field of knowledge: Health Sciences - Medicine
• Cooperation agreement: CNPq - INCTs
• Principal researcher: Jaime Eduardo Cecilio Hallak
• Grantee: Jaime Eduardo Cecilio Hallak
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais:( Atuais ): Acioly Luiz Tavares de Lacerda ; Antonio Lucio Teixeira Junior ; Antonio Waldo Zuardi ; Danielle Macedo Gaspar ; Flavio Pereira Kapczinski ; João Paulo Maia de Oliveira ; José Alexandre de Souza Crippa ; Maria Eugênia Queiroz Nassur ; Nadja Schroder ; Ricardo Machado Xavier ; Vanessa Costhek Abílio
• Pesquisadores principais:( Anteriores ): Mirian Akemi Furuie Hayashi
• Associated scholarship(s): 22/00211-0 - Sodium nitroprusside action mechanisms as a preventive therapeutic strategy for Schizophrenia, BP.DR; 19/22120-4 - Systemic treatment with cannabidiol in rats of high and low freezing carioca lines in the chronic pain model: evaluation of pain sensitivity, affective component of pain, anxiety and its expression of BDNF, BP.DR; 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders, BP.DR; 19/02787-4 - Effects of cannabidiol vehiculated in nanoemulsion in rats submitted to the chemical model of temporal lobe epilepsy, BP.IC; 18/06877-5 - Systemic treatment with canabidiol in a neuropathic pain model: evaluation of the sensorial-discriminative and emotional-motivacional components pain sensitivity, BP.DR

Abstract

The National Institute of Translational Medicine (NITM) was created in 2008 with the purpose of establishing a national network of research centers with outstanding experience in the investigation of biomarkers and new therapeutic targets and molecules in neuropsychiatric disorders, acting in the strategic area of Health and Medicines defined by the Federal Government. In the base of all activities of the NITM, translational research aims to streamline the application of findings from basic research in clinical settings and offers important possibilities for Brazil to develop its potential to generate innovation from its academic production. Surpassing its original goals, the groups of the NITM published more than 600 articles in international journals and 9 patent applications. In qualitative terms, the NITM produced important findings regarding the role of neurotrophins (particularly BNDF, Brain-Derived Neurotrophic Factor) and of new drugs as cannabidiol (CBD) and sodium nitroprusside (SNP) in the context of neuropsychiatric disorders. The institute also had a significant performance in the training and improvement of human resources, with the exchange of researchers among national and international research centers and the defense of many doctoral theses and master’s dissertations, in addition to fostering the transfer of scientific knowledge to the community and the productive sector and favoring the insertion of national groups in the international context of world-class research. In its current proposal, with a group formed by around 90 PhDs distributed over 8 research centers in South, Southeast and Northeast Brazil, the NITM will act in all the areas mentioned above, especially the investigation on promising molecules for the treatment of neuropsychiatric symptoms and disorders (CBD, SNP, ayahuasca, N-acetylcysteine, among others) in the effort to increase the productivity and representativeness of Brazilian research through the production of knowledge and innovation with potential to yield dividends for the country and member institutions of the NITM. (AU)

Scientific publications

(30)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GINER-MURILLO, MARIA; ATIENZA-CARBONELL, BEATRIZ; CERVERA-MARTINEZ, JOSE; BOBES-BASCARAN, TERESA; CRESPO-FACORRO, BENEDICTO; DE BONI, RAQUEL B.; ESTEBAN, CRISTINA; GARCIA-PORTILLA, MARIA PAZ; GOMES-DA-COSTA, SUSANA; GONZALEZ-PINTO, ANA; et al. Lifestyle in Undergraduate Students and Demographically Matched Controls during the COVID-19 Pandemic in Spain. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 15, AUG 2021. (14/50891-1)

CARVALHO OLIVEIRA, IGOR GUSTAVO; COSTA QUEIROZ, MARIA EUGENIA. A micro salting-out assisted liquid-liquid extraction combined with ultra-high performance liquid chromatography tandem mass spectrometry to determine anandamide and 2-arachidonoylglycerol in rat brain samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1158, NOV 20 2020. (14/50891-1, 17/02147-0)

DE CARVALHO PORTA, LUCAS; FADEL, VALMIR; D'ARC CAMPEIRO, JOANA; OLIVEIRA, EDUARDO BRANDT; GODINHO, ROSELY OLIVEIRA; HAYASHI, MIRIAN AKEMI FURUIE. Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 98, n. 11, SEP 2020. (14/50891-1, 17/02413-1, 18/20014-0, 18/21381-6)

LAZARINI-LOPES, WILLIAN; DO VAL-DA SILVA, RAQUEL A.; DA SILVA-JUNIOR, RUI M. P.; CUNHA, ALEXANDRA O. S.; GARCIA-CAIRASCO, NORBERTO. Cannabinoids in Audiogenic Seizures: From Neuronal Networks to Future Perspectives for Epilepsy Treatment. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 15, FEB 11 2021. (19/05957-8, 19/00849-2, 14/50891-1)

DE BONI, RAQUEL BRANDINI; BALANZA-MARTINEZ, VICENT; MOTA, JUREMA CORREA; CARDOSO, TAIANE DE AZEVEDO; BALLESTER, PEDRO; ATIENZA-CARBONELL, BEATRIZ; BASTOS, I, FRANCISCO; KAPCZINSKI, FLAVIO. Depression, Anxiety, and Lifestyle Among Essential Workers: A Web Survey From Brazil and Spain During the COVID-19 Pandemic. JOURNAL OF MEDICAL INTERNET RESEARCH, v. 22, n. 10, OCT 30 2020. (14/50891-1)

DE MEDEIROS RAMALHO, IZOLA MORAIS; PEREIRA, DANIEL TORRES; LIMA GALVAO, GIOVANNA BRUNELLY; FREIRE, DANIELLE TEIXEIRA; AMARAL-MACHADO, LUCAS; ALENCAR, EVERTON DO NASCIMENTO; TABOSA DO EGITO, ERYVALDO SOCRATES. Current trends on cannabidiol delivery systems: where are we and where are we going?. Expert Opinion on Drug Delivery, v. 18, n. 11, JUL 2021. (14/50891-1)

CORAL RAKOVSKI; TAIANE DE AZEVEDO CARDOSO; JUREMA CORRÊA DA MOTA; FRANCISCO I. BASTOS; FLAVIO KAPCZINSKI; RAQUEL BRANDINI DE BONI. Underage drinking in Brazil: findings from a community household survey. Revista Brasileira de Psiquiatria, v. 44, n. 3, p. 257-263, 2021-12-15. (14/50891-1)

MARIO SIMJANOSKI; PEDRO L. BALLESTER; JUREMA CORRÊA DA MOTA; RAQUEL B. DE BONI; VICENT BALANZÁ-MARTÍNEZ; BEATRIZ ATIENZA-CARBONELL; FRANCISCO I. BASTOS; BENICIO N. FREY; LUCIANO MINUZZI; TAIANE DE AZEVEDO CARDOSO; et al. Lifestyle predictors of depression and anxiety during COVID-19: a machine learning approach. Trends in Psychiatry and Psychotherapy, v. 44, 2022-05-30. (14/50891-1)

LAZARINI-LOPES, WILLIAN; DO VAL-DA SILVA, RAQUEL A.; DA SILVA-JUNIOR, RUI M. P.; LEITE, JOAO P.; GARCIA-CAIRASCO, NORBERTO. The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 111, p. 166-182, APR 2020. (19/05957-8, 14/50891-1, 19/00849-2)

DAMASCENO, SAMARA; GOMEZ-NIETO, RICARDO; GARCIA-CAIRASCO, NORBERTO; JAVIER HERRERO-TURRION, MANUEL; MARIN, FAUSTINO; LOPEZ, DOLORES E.. Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal. FRONTIERS IN NEUROLOGY, v. 11, FEB 13 2020. (14/50891-1)

GARCIA-CAIRASCO, NORBERTO; PODOLSKY-GONDIM, GUILHERME; TEJADA, JULIAN. Searching for a paradigm shift in the research on the epilepsies and associated neuropsychiatric comorbidities. From ancient historical knowledge to the challenge of contemporary systems complexity and emergent functions. Epilepsy & Behavior, v. 121, n. B, AUG 2021. (19/05957-8, 14/50891-1)

MAIA BEZERRA, NATHALIA KAREN; DE MENEZES GALVAO, ANA CECILIA; MARTINS LEITE, NATHALIA EVELYN; LEAO BARBALHO SANT'ANNA, ADRIANA; DE MEDEIROS GARCIA TORRES, MYCHELLE; GALVAO PINTO COELHO, MARIA CECILIA; KENJI MEDEIROS SHIRAMIZU, VICTOR; DE SOUSA, MARIA BERNARDETE CORDEIRO; LEITE GALVAO-COELHO, NICOLE. Success ofin vitrofertilization and its association with the levels of psychophysiological stress before and during the treatment. HEALTH CARE FOR WOMEN INTERNATIONAL, v. 42, n. 4-6, p. 420-445, JUL 1 2021. (14/50891-1)

CORAL RAKOVSKI; TAIANE DE AZEVEDO CARDOSO; JUREMA CORRÊA DA MOTA; FRANCISCO I. BASTOS; FLAVIO KAPCZINSKI; RAQUEL BRANDINI DE BONI. Underage drinking in Brazil: findings from a community household survey. Revista Brasileira de Psiquiatria, 2021-12-15. (14/50891-1)

RODRIGUEZ, BENJAMIN; NANI, JOAO VICTOR; ALMEIDA, PRISCILA G. C.; BRIETZKE, ELISA; LEE, RICHARD S.; HAYASHI, MIRIAN A. F.. Neuropeptides and oligopeptidases in schizophrenia. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 108, p. 679-693, JAN 2020. (14/50867-3, 14/50891-1, 17/02413-1, 14/18938-8, 19/09207-3)

NANI, V, JOAO; ALMEIDA, PRISCILA G. C.; NOTO, CRISTIANO; BRESSAN, RODRIGO A.; BRIETZKE, ELISA; HAYASHI, MIRIAN A. F.. Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia. NORDIC JOURNAL OF PSYCHIATRY, JAN 2022. (19/09207-3, 18/20014-0, 17/02413-1, 14/50891-1)

BALLESTER, PEDRO L.; CARDOSO, TAIANE DE A.; MOREIRA, FERNANDA PEDROTTI; SILVA, RICARDO A. DA; MONDIN, THAISE CAMPOS; ARAUJO, RICARDO M.; KAPCZINSKI, FLAVIO; FREY, BENICIO N.; JANSEN, KAREN; SOUZA, LUCIANO D. DE MATTOS. 5-year incidence of suicide-risk in youth: A gradient tree boosting and SHAP study. Journal of Affective Disorders, v. 297, p. 1049-1056, JAN 15 2022. (14/50891-1)

BALLESTER, PEDRO L.; CARDOSO, TAIANE DE A.; MOREIRA, FERNANDA PEDROTTI; DA SILVA, RICARDO A.; MONDIN, THAISE CAMPOS; ARAUJO, RICARDO M.; KAPCZINSKI, FLAVIO; FREY, BENICIO N.; JANSEN, KAREN; DE MATTOS SOUZA, LUCIANO D.. -year incidence of suicide-risk in youth: A gradient tree boosting and SHAP stud. Journal of Affective Disorders, v. 295, p. 1049-1056, DEC 1 2021. (14/50891-1)

SILVA-CARDOSO, GLEICE K.; LAZARINI-LOPES, WILLIAN; HALLAK, JAIME E.; CRIPPA, JOSE A.; ZUARDI, ANTONIO W.; GARCIA-CAIRASCO, NORBERTO; LEITE-PANISSI, CHRISTIE R. A.. Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors. Neuropharmacology, v. 197, OCT 1 2021. (19/05957-8, 18/06877-5, 14/50891-1)

OSORIO, FLAVIA L.; LOUREIRO, SONIA REGINA; HALLAK, JAIME EDUARDO C.; MACHADO-DE-SOUSA, JOAO PAULO; USHIROHIRA, JULIANA M.; BAES, CRISTIANE V. W.; APOLINARIO, THIAGO D.; DONADON, MARIANA F.; BOLSONI, LIVIA M.; GUIMARAES, THIAGO; et al. Clinical validity and intrarater and test-retest reliability of the Structured Clinical Interview for DSM-5-Clinician Version (SCID-5-CV). PSYCHIATRY AND CLINICAL NEUROSCIENCES, v. 73, n. 12, p. 754-760, DEC 2019. (14/50891-1, 17/18000-8)

NANI, V, JOAO; FONSECA, MATHEUS C.; ENGI, SHEILA A.; PERILLO, MAYARA G.; DIAS, CARLOS S. B.; GAZARINI, MARCOS L.; KORTH, CARSTEN; CRUZ, FABIO C.; HAYASHI, MIRIAN A. F.. Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. JOURNAL OF PSYCHOPHARMACOLOGY, v. 34, n. 4, JAN 2020. (14/50891-1, 18/20014-0, 17/02413-1, 19/09207-3)

TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C.. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2, FEB 2021. (18/20014-0, 16/05311-2, 18/07366-4, 14/50891-1, 19/13112-8, 15/26328-8, 16/18277-7, 12/50880-4, 17/02413-1)

TASIC, LJUBICA; LARCERDA, ACIOLY L. T.; PONTES, JOAO G. M.; DA COSTA, TASSIA B. B. C.; NANI, V, JOAO; MARTINS, LUCAS GELAIN; SANTOS, LEONARDO A.; NUNES, MARIELLE F. Q.; ADELINO, MARCELO P. M.; PEDRINI, MARIANA; et al. Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder. JOURNAL OF PSYCHIATRIC RESEARCH, v. 119, p. 67-75, DEC 2019. (14/50867-3, 14/50891-1, 14/18938-8)

VALIM BRIGANTE, TAMIRES AMABILE; ABE, FLAVIA R.; ZUARDI, ANTONIO WALDO; CECILIO HALLAK, JAIME EDUARDO; CRIPPA, JOSE ALEXANDRE S.; DE OLIVEIRA, DANIELLE P.. Cannabidiol did not induce teratogenicity or neurotoxicity in exposed zebrafish embryos. Chemico-Biological Interactions, v. 291, p. 81-86, AUG 1 2018. (14/50891-1, 16/03281-9)

TILELLI, CRISTIANE QUEIXA; FLORES, LARISSA RIBEIRO; COTA, VINICIUS ROSA; DE CASTRO, OLAGIDE WAGNER; GARCIA-CAIRASCO, NORBERTO. Amygdaloid complex anatomopathological findings in animal models of status epilepticus. Epilepsy & Behavior, v. 121, n. B, AUG 2021. (14/50891-1, 19/05957-8)

VALENTIM-LIMA, EVANDRO; DE OLIVEIRA, JOSE ANTONIO CORTES; ANTUNES-RODRIGUES, JOSE.; REIS, LUIS CARLOS; GARCIA-CAIRASCO, NORBERTO; MECAWI, ANDRE S.. Neuroendocrine changes in the hypothalamic-neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling. Journal of Neuroendocrinology, v. 33, n. 7, SI, JUL 2021. (19/05957-8, 14/50891-1, 14/15218-4, 13/09799-1)

ALVES, SUELEN SANTOS; PATRICIO DA SILVA-JUNIOR, RUI MILTON; SERVILHA-MENEZES, GABRIEL; HOMOLAK, JAN; SALKOVIC-PETRISIC, MELITA; GARCIA-CAIRASCO, NORBERTO. Insulin Resistance as a Common Link Between Current Alzheimer's Disease Hypotheses. JOURNAL OF ALZHEIMER'S DISEASE, v. 82, n. 1, p. 71-105, 2021. (19/00849-2, 19/05957-8, 14/50891-1, 19/02787-4)

LAZARINI-LOPES, WILLIAN; DA SILVA-JUNIOR, RUI M. P.; SERVILHA-MENEZES, GABRIEL; DO VAL-DA SILVA, RAQUEL A.; GARCIA-CAIRASCO, NORBERTO. Cannabinoid Receptor Type 1 (CB1R) Expression in Limbic Brain Structures After Acute and Chronic Seizures in a Genetic Model of Epilepsy. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 14, DEC 21 2020. (19/00849-2, 19/02787-4, 14/50891-1, 19/05957-8)

CARVALHO OLIVEIRA, IGOR GUSTAVO; DE SOUZA, ISRAEL DONIZETI; DO NASCIMENTO, GLAUCE CRIVELARO; DEL BEL, ELAINE; COSTA QUEIROZ, MARIA EUGENIA. In-tube solid-phase microextraction directly coupled to tandem mass spectrometry for anandamide and 2-arachidonoylglycerol determination in rat brain samples from an animal model of Parkinson's disease. Journal of Chromatography A, v. 1636, JAN 11 2021. (19/19485-0, 18/06068-0, 20/00126-8, 14/50891-1)

CRIPPA, JOSE ALEXANDRE S.; PACHECO, JULIA COZAR; ZUARDI, ANTONIO W.; GUIMARAES, FRANCISCO S.; CAMPOS, ALLINE CRISTINA; LIMA OSORIO, FLAVIA DE; LOUREIRO, SONIA REGINA; DOS SANTOS, RAFAEL G.; SOUZA, JOSE DIOGO S.; USHIROHIRA, JULIANA MAYUMI; et al. Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. CANNABIS AND CANNABINOID RESEARCH, OCT 2021. (14/50891-1)

OSORIO, FLAVIA L.; MACHADO SILVEIRA, ISABELLA LARA; PEREIRA-LIMA, KARINA; DE SOUZA CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; LOUREIRO, SONIA REGINA. Risk and Protective Factors for the Mental Health of Brazilian Healthcare Workers in the Frontline of COVID-19 Pandemic. FRONTIERS IN PSYCHIATRY, v. 12, JUL 28 2021. (14/50891-1)