INCT 2014: Translational Medicine

• Grant number: 14/50891-1
• Support type: Research Projects - Thematic Grants
• Duration: July 01, 2017 - June 30, 2023
• Field of knowledge: Health Sciences - Medicine
• Cooperation agreement: CNPq - INCTs
• Principal Investigator: Jaime Eduardo Cecilio Hallak
• Grantee: Jaime Eduardo Cecilio Hallak
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Co-Principal Investigators: Acioly Luiz Tavares de Lacerda ; Antonio Lucio Teixeira Junior ; Antonio Waldo Zuardi ; Danielle Macedo Gaspar ; Flavio Pereira Kapczinski ; João Paulo Maia de Oliveira ; José Alexandre de Souza Crippa ; Maria Eugênia Queiroz Nassur ; Mirian Akemi Furuie Hayashi ; Nadja Schroder ; Ricardo Machado Xavier ; Vanessa Costhek Abílio
• Associated scholarship(s): 19/22120-4 - Systemic treatment with cannabidiol in rats of high and low freezing carioca lines in the chronic pain model: evaluation of pain sensitivity, affective component of pain, anxiety and its expression of BDNF, BP.DR; 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders, BP.DR; 19/02787-4 - Effects of cannabidiol vehiculated in nanoemulsion in rats submitted to the chemical model of temporal lobe epilepsy, BP.IC; 18/06877-5 - Systemic treatment with canabidiol in a neuropathic pain model: evaluation of the sensorial-discriminative and emotional-motivacional components pain sensitivity, BP.DR

Abstract

The National Institute of Translational Medicine (NITM) was created in 2008 with the purpose of establishing a national network of research centers with outstanding experience in the investigation of biomarkers and new therapeutic targets and molecules in neuropsychiatric disorders, acting in the strategic area of Health and Medicines defined by the Federal Government. In the base of all activities of the NITM, translational research aims to streamline the application of findings from basic research in clinical settings and offers important possibilities for Brazil to develop its potential to generate innovation from its academic production. Surpassing its original goals, the groups of the NITM published more than 600 articles in international journals and 9 patent applications. In qualitative terms, the NITM produced important findings regarding the role of neurotrophins (particularly BNDF, Brain-Derived Neurotrophic Factor) and of new drugs as cannabidiol (CBD) and sodium nitroprusside (SNP) in the context of neuropsychiatric disorders. The institute also had a significant performance in the training and improvement of human resources, with the exchange of researchers among national and international research centers and the defense of many doctoral theses and master’s dissertations, in addition to fostering the transfer of scientific knowledge to the community and the productive sector and favoring the insertion of national groups in the international context of world-class research. In its current proposal, with a group formed by around 90 PhDs distributed over 8 research centers in South, Southeast and Northeast Brazil, the NITM will act in all the areas mentioned above, especially the investigation on promising molecules for the treatment of neuropsychiatric symptoms and disorders (CBD, SNP, ayahuasca, N-acetylcysteine, among others) in the effort to increase the productivity and representativeness of Brazilian research through the production of knowledge and innovation with potential to yield dividends for the country and member institutions of the NITM. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAZARINI-LOPES, WILLIAN; DO VAL-DA SILVA, RAQUEL A.; DA SILVA-JUNIOR, RUI M. P.; CUNHA, ALEXANDRA O. S.; GARCIA-CAIRASCO, NORBERTO. Cannabinoids in Audiogenic Seizures: From Neuronal Networks to Future Perspectives for Epilepsy Treatment. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 15, FEB 11 2021. Web of Science Citations: 0.

TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2 FEB 2021. Web of Science Citations: 0.

CARVALHO OLIVEIRA, IGOR GUSTAVO; DE SOUZA, ISRAEL DONIZETI; DO NASCIMENTO, GLAUCE CRIVELARO; DEL BEL, ELAINE; COSTA QUEIROZ, MARIA EUGENIA. In-tube solid-phase microextraction directly coupled to tandem mass spectrometry for anandamide and 2-arachidonoylglycerol determination in rat brain samples from an animal model of Parkinson's disease. Journal of Chromatography A, v. 1636, JAN 11 2021. Web of Science Citations: 0.

LAZARINI-LOPES, WILLIAN; DA SILVA-JUNIOR, RUI M. P.; SERVILHA-MENEZES, GABRIEL; DO VAL-DA SILVA, RAQUEL A.; GARCIA-CAIRASCO, NORBERTO. Cannabinoid Receptor Type 1 (CB1R) Expression in Limbic Brain Structures After Acute and Chronic Seizures in a Genetic Model of Epilepsy. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 14, DEC 21 2020. Web of Science Citations: 0.

CARVALHO OLIVEIRA, IGOR GUSTAVO; COSTA QUEIROZ, MARIA EUGENIA. A micro salting-out assisted liquid-liquid extraction combined with ultra-high performance liquid chromatography tandem mass spectrometry to determine anandamide and 2-arachidonoylglycerol in rat brain samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1158, NOV 20 2020. Web of Science Citations: 0.

DE BONI, RAQUEL BRANDINI; BALANZA-MARTINEZ, VICENT; MOTA, JUREMA CORREA; CARDOSO, TAIANE DE AZEVEDO; BALLESTER, PEDRO; ATIENZA-CARBONELL, BEATRIZ; BASTOS, I, FRANCISCO; KAPCZINSKI, FLAVIO. Depression, Anxiety, and Lifestyle Among Essential Workers: A Web Survey From Brazil and Spain During the COVID-19 Pandemic. JOURNAL OF MEDICAL INTERNET RESEARCH, v. 22, n. 10 OCT 30 2020. Web of Science Citations: 0.

DE CARVALHO PORTA, LUCAS; FADEL, VALMIR; D'ARC CAMPEIRO, JOANA; OLIVEIRA, EDUARDO BRANDT; GODINHO, ROSELY OLIVEIRA; HAYASHI, MIRIAN AKEMI FURUIE. Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine. JOURNAL OF MOLECULAR MEDICINE-JMM, v. 98, n. 11 SEP 2020. Web of Science Citations: 0.

MAIA BEZERRA, NATHALIA KAREN; DE MENEZES GALVAO, ANA CECILIA; MARTINS LEITE, NATHALIA EVELYN; LEAO BARBALHO SANT'ANNA, ADRIANA; DE MEDEIROS GARCIA TORRES, MYCHELLE; GALVAO PINTO COELHO, MARIA CECILIA; KENJI MEDEIROS SHIRAMIZU, VICTOR; DE SOUSA, MARIA BERNARDETE CORDEIRO; LEITE GALVAO-COELHO, NICOLE. Success ofin vitrofertilization and its association with the levels of psychophysiological stress before and during the treatment. HEALTH CARE FOR WOMEN INTERNATIONAL, JUL 2020. Web of Science Citations: 0.

LAZARINI-LOPES, WILLIAN; DO VAL-DA SILVA, RAQUEL A.; DA SILVA-JUNIOR, RUI M. P.; LEITE, JOAO P.; GARCIA-CAIRASCO, NORBERTO. The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 111, p. 166-182, APR 2020. Web of Science Citations: 0.

DAMASCENO, SAMARA; GOMEZ-NIETO, RICARDO; GARCIA-CAIRASCO, NORBERTO; JAVIER HERRERO-TURRION, MANUEL; MARIN, FAUSTINO; LOPEZ, DOLORES E. Top Common Differentially Expressed Genes in the Epileptogenic Nucleus of Two Strains of Rodents Susceptible to Audiogenic Seizures: WAR and GASH/Sal. FRONTIERS IN NEUROLOGY, v. 11, FEB 13 2020. Web of Science Citations: 0.

NANI, V, JOAO; FONSECA, MATHEUS C.; ENGI, SHEILA A.; PERILLO, MAYARA G.; DIAS, CARLOS S. B.; GAZARINI, MARCOS L.; KORTH, CARSTEN; CRUZ, FABIO C.; HAYASHI, MIRIAN A. F. Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. JOURNAL OF PSYCHOPHARMACOLOGY, v. 34, n. 4 JAN 2020. Web of Science Citations: 0.

RODRIGUEZ, BENJAMIN; NANI, JOAO VICTOR; ALMEIDA, PRISCILA G. C.; BRIETZKE, ELISA; LEE, RICHARD S.; HAYASHI, MIRIAN A. F. Neuropeptides and oligopeptidases in schizophrenia. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 108, p. 679-693, JAN 2020. Web of Science Citations: 0.

OSORIO, FLAVIA L.; LOUREIRO, SONIA REGINA; HALLAK, JAIME EDUARDO C.; MACHADO-DE-SOUSA, JOAO PAULO; USHIROHIRA, JULIANA M.; BAES, CRISTIANE V. W.; APOLINARIO, THIAGO D.; DONADON, MARIANA F.; BOLSONI, LIVIA M.; GUIMARAES, THIAGO; FRACON, VICTOR S.; SILVA-RODRIGUES, ANA PAULA CASAGRANDE; PIZETA, FERNANDA AGUIAR; SOUZA, ROBERTO MASCARENHAS; SANCHES, RAFAEL FARIA; DOS SANTOS, RAFAEL G.; MARTIN-SANTOS, ROCIO; CRIPPA, JOSE ALEXANDRE S. Clinical validity and intrarater and test-retest reliability of the Structured Clinical Interview for DSM-5-Clinician Version (SCID-5-CV). PSYCHIATRY AND CLINICAL NEUROSCIENCES, v. 73, n. 12, p. 754-760, DEC 2019. Web of Science Citations: 2.

TASIC, LJUBICA; LARCERDA, ACIOLY L. T.; PONTES, JOAO G. M.; DA COSTA, TASSIA B. B. C.; NANI, V, JOAO; MARTINS, LUCAS GELAIN; SANTOS, LEONARDO A.; NUNES, MARIELLE F. Q.; ADELINO, MARCELO P. M.; PEDRINI, MARIANA; CORDEIRO, QUIRINO; DE SANTANA, FELIPE BACHION; POPPI, RONEI J.; BRIETZKE, ELISA; FURUIE HAYASHI, MIRIAN AKEMI. Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder. JOURNAL OF PSYCHIATRIC RESEARCH, v. 119, p. 67-75, DEC 2019. Web of Science Citations: 0.

VALIM BRIGANTE, TAMIRES AMABILE; ABE, FLAVIA R.; ZUARDI, ANTONIO WALDO; CECILIO HALLAK, JAIME EDUARDO; CRIPPA, JOSE ALEXANDRE S.; DE OLIVEIRA, DANIELLE P. Cannabidiol did not induce teratogenicity or neurotoxicity in exposed zebrafish embryos. Chemico-Biological Interactions, v. 291, p. 81-86, AUG 1 2018. Web of Science Citations: 7.