| Full text | |
| Author(s): |
Lazarini-Lopes, Willian
[1, 2]
;
Do Val-da Silva, Raquel A.
[1]
;
da Silva-Junior, Rui M. P.
[2]
;
Cunha, Alexandra O. S.
[3]
;
Garcia-Cairasco, Norberto
[1, 3, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Neurosci & Behav Sci Dept, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Physiol Dept, Neurophysiol & Expt Neuroethol Lab LNNE, Sao Paulo - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Physiol Dept, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN BEHAVIORAL NEUROSCIENCE; v. 15, FEB 11 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Cannabinoids and Cannabis-derived compounds have been receiving especial attention in the epilepsy research scenario. Pharmacological modulation of endocannabinoid system's components, like cannabinoid type 1 receptors (CB1R) and their bindings, are associated with seizures in preclinical models. CB1R expression and functionality were altered in humans and preclinical models of seizures. Additionally, Cannabis-derived compounds, like cannabidiol (CBD), present anticonvulsant activity in humans and in a great variety of animal models. Audiogenic seizures (AS) are induced in genetically susceptible animals by high-intensity sound stimulation. Audiogenic strains, like the Genetically Epilepsy Prone Rats, Wistar Audiogenic Rats, and Krushinsky-Molodkina, are useful tools to study epilepsy. In audiogenic susceptible animals, acute acoustic stimulation induces brainstem-dependent wild running and tonic-clonic seizures. However, during the chronic protocol of AS, the audiogenic kindling (AuK), limbic and cortical structures are recruited, and the initially brainstem-dependent seizures give rise to limbic seizures. The present study reviewed the effects of pharmacological modulation of the endocannabinoid system in audiogenic seizure susceptibility and expression. The effects of Cannabis-derived compounds in audiogenic seizures were also reviewed, with especial attention to CBD. CB1R activation, as well Cannabis-derived compounds, induced anticonvulsant effects against audiogenic seizures, but the effects of cannabinoids modulation and Cannabis-derived compounds still need to be verified in chronic audiogenic seizures. The effects of cannabinoids and Cannabis-derived compounds should be further investigated not only in audiogenic seizures, but also in epilepsy related comorbidities present in audiogenic strains, like anxiety, and depression. (AU) | |
| FAPESP's process: | 19/05957-8 - Epilepsies and neuropsyquiatric comorbidities: characterization of the effects of the treatment with cannabidiol and HUF-101 in in vivo and in vitro experimental models |
| Grantee: | Norberto Garcia Cairasco |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/00849-2 - Uncovering pathophysiological and molecular mechanisms involved in tumorigenesis by platforms for next-generation sequencing (NGS) |
| Grantee: | Rui Milton Patrício da Silva Junior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/50891-1 - INCT 2014: Translational Medicine |
| Grantee: | Jaime Eduardo Cecilio Hallak |
| Support Opportunities: | Research Projects - Thematic Grants |