Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study

Author(s)

Neves, Fabio Fernandes ; Pott-Junior, Henrique ; Yamashita, Kaori Maria Carolina ; Santos, Sigrid de Sousa ; Cominetti, Marcia Regina ; Freire, Caio Cesar de Melo ; da Cunha, Anderson Ferreira ; Jordao, Alceu Afonso

• Document type: Journal article
• Source: Free Radical Biology and Medicine; v. 207, p. 6-pg., 2023-10-01.

Abstract

In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates reactive oxygen species levels, harms cell structures, and directly increases disease severity and mortality. We aimed to evaluate whether plasma oxidative stress biomarker levels could predict mortality in adults admitted with Coronavirus Disease 2019 (COVID-19), considering potential confounders. We conducted a cohort study of 115 adults (62.1 +/- 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Serum levels of a-tocopherol, glutathione, superoxide dismutase, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, and advanced oxidation protein products were quantified at COVID-19 diagnosis using real-time polymerase chain reaction. Serum levels of a-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products differed significantly between survivors and non-survivors. Serum glutathione levels below 327.2 mu mol/ mL were associated with a significant risk of death in COVID-19 patients, even after accounting for other factors (adjusted hazard ratio = 3.12 [95% CI: 1.83-5.33]). (AU)

• FAPESP's process: 20/06725-0 - Serum vitamin D levels in COVID-19 patients: prevalence of hypovitaminosis and associated factors
• Grantee: Fábio Fernandes Neves
• Support Opportunities: Regular Research Grants