Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities

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Silva, Amanda A. ; Frajacomo, Silmara C. L. ; Cruz, Allefe B. ; Buglio, Kaio Eduardo ; Affonso, Daniele Daiane ; Portes, Marcelo Cecconi ; Ruiz, Ana Lucia T. G. ; de Carvalho, Joao Ernesto ; Lustri, Wilton R. ; Pereira, Douglas H. ; Ferreira, Ana M. da Costa ; Corbi, Pedro P.

• Document type: Journal article
• Source: INORGANICS; v. 11, n. 8, p. 21-pg., 2023-08-01.

Abstract

The growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive ligands and metals that are already consolidated in the synthesis of metallopharmaceutical agents. Thus, this work deals with the synthesis, characterization, and study of naproxen (Nap)-based complexes of copper(II) and platinum(II) as antiproliferative agents. The copper complex (Cu-Nap) presents a binuclear paddle-wheel structure in a 1 Cu:2 Nap:1 H2O molar composition, in which Cu(II) is bonded to the carboxylate oxygens from naproxenate in a bidentate bridging mode. The platinum complex (Pt-Nap) was identified as the square planar cis-[Pt(Nap)(2)(DMSO)(2)] isomer, in which Pt(II) is bonded to the carboxylate oxygen atom of Nap in a monodentate fashion. Both complexes were inactive against the Gram-positive and Gram-negative bacterial strains assessed. Pt-Nap presented low cytostatic behavior over a set of tumor cells, but good viability for normal cells, while Cu-Nap was cytotoxic against all cells, with a cytocidal activity against glioma tumor cells. (AU)

• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/12062-4 - Synthesis, characterization and studies of interaction with biomolecules of metal complexes containing biologically active ligands: a strategy in the preparation of new agents with antibacterial and antiviral activities
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/07458-9 - Use of varied nutrient sources and agro-industrial residues in the production of bacterial cellulose for topical application as a support for sustained release of (metal) antibacterial and antitumor drugs
• Grantee: Wilton Rogério Lustri
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/10265-8 - Cancer Theranostics Innovation Center (CancerThera)
• Grantee: Carmino Antonio de Souza
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 11/01114-4 - Antiproliferative and (anti)hormonal activities of extracts and fractions obtained from some Mentha species
• Grantee: Ana Lúcia Tasca Gois Ruiz
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/23950-7 - In vitro evaluation of (anti)mutagenic activity of an aporphine alkaloid and its synthetic intermediates
• Grantee: Tamires Carolina Sedano
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 21/08717-8 - Synthesis of copper, silver and gold complexes involving nucleotide analogues in the search of new alternatives for the treatment of ovarian cancer
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants