Terpenes extracted from marine sponges with antioxidant activity: a systematic review

Author(s)

Martignago, Cintia Cristina Santi ; Soares-Silva, Beatriz ; Parisi, Julia Risso ; Silva, Lais Caroline Souza e ; Granito, Renata Neves ; Ribeiro, Alessandra Mussi ; Renno, Ana Claudia Muniz ; de Sousa, Lorena Ramos Freitas ; Aguiar, Anna Caroline Campos

• Document type: Journal article
• Source: NATURAL PRODUCTS AND BIOPROSPECTING; v. 13, n. 1, p. 12-pg., 2023-12-01.

Abstract

Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge's secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro. Searching in three different databases, two hundred articles were selected. After screening abstracts, titles and evaluating for eligibility of manuscripts 14 articles were included. The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) and measurement of intracellular reactive oxygen species (ROS). It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro. Scientific evidence of the studies included in this review was accessed by the GRADE analysis. Terpenes play an important ecological role, moreover these molecules have a pharmaceutical and industrial application. (AU)

• FAPESP's process: 19/10228-5 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system
• Grantee: Ana Claudia Muniz Renno
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/19708-0 - Identification of new antimalarial compounds: a multidisciplinary strategy aimed to search for potent chemical classes against new molecular targets and different stages of life of Plasmodium spp
• Grantee: Anna Caroline Campos Aguiar
• Support Opportunities: Research Grants - Young Investigators Grants