The insulin resistance is reversed by exogenous 3,5,3 ' triiodothyronine in type 2 diabetic Goto-Kakizaki rats by an inflammatory-independent pathway

Author(s)

Panveloski-Costa, Ana Carolina ; Tatagiba Kuwabara, Wilson Mitsuo ; Munhoz, Ana Claudia ; Lucena, Camila Ferraz ; Curi, Rui ; Carpinelli, Angelo Rafael ; Nunes, Maria Tereza

• Document type: Journal article
• Source: ENDOCRINE; v. 68, n. 2, p. 9-pg., 2020-01-29.

Abstract

Purpose Diabetes mellitus (DM) has a multifactorial etiology that imparts a particular challenge to effective pharmacotherapy. Thyroid hormone actions have demonstrated beneficial effects in diabetic as well as obese rats. In both conditions, inflammation status plays a crucial role in the development of insulin resistance. Taking this into consideration, the present study aimed to demonstrate another possible pathway of thyroid hormone action on insulin sensitivity in a spontaneous type 2 diabetic rat model: the Goto-Kakizaki (GK) rats. GK animals present all typical hallmarks of type 2 DM (T2DM), except the usual peripheric inflammatory condition, observed in the other T2DM animal models. Methods GK rats were treated or not with 3,5,3 ' triiodothyronine (T3). Insulin sensitivity, glucose tolerance, and proteins related to glucose uptake and utilization were evaluated in the skeletal muscle, white adipose tissue, and liver. Results GK rats T3-treated presented enhanced insulin sensitivity, increased GLUT-4 content in the white adipose tissue and skeletal muscle, and increased hexokinase and citrate synthase content in skeletal muscle. Both non-treated and T3-treated GK rats did not present alterations in cytokine content in white adipose tissue, skeletal muscle, liver, and serum. Conclusions These results indicate that T3 improves insulin sensitivity in diabetic rats by a novel inflammatory-independent mechanism. (AU)

• FAPESP's process: 13/05629-4 - Genomic vs nongenomic actions of thyroid hormones: changes of paradigms, physiological implications and therapeutical perspectives
• Grantee: Maria Tereza Nunes
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/21875-6 - Triiodothyronine (T3) treatment effects on miRNA expression profile in type 1 diabetes mellitus and obesity: importance and therapeutic implications
• Grantee: Ana Carolina Panveloski Costa Salomão
• Support Opportunities: Scholarships in Brazil - Post-Doctoral