| Full text | |
| Author(s): |
Reis, Fernando M. C. V.
;
Mobbs, Dean
;
Canteras, Newton S.
;
Adhikari, Avishek
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Neuropharmacology; v. 228, p. 11-pg., 2023-02-14. |
| Abstract | |
The midbrain periaqueductal gray (PAG) has been recognized for decades as having a central role in the control of a wide variety of defensive responses. Initial discoveries relied primarily on lesions, electrical stimulation and pharmacology. Recent developments in neural activity imaging and in methods to control activity with anatomical and genetic specificity have revealed additional streams of data informing our understanding of PAG function. Here, we discuss both classic and modern studies reporting on how PAG-centered circuits influence innate as well as learned defensive actions in rodents and humans. Though early discoveries emphasized the PAG's role in rapid induction of innate defensive actions, emerging new data indicate a prominent role for the PAG in more complex processes, including representing behavioral states and influencing fear learning and memory. (AU) | |
| FAPESP's process: | 14/05432-9 - Neural bases of fear and aggression |
| Grantee: | Newton Sabino Canteras |
| Support Opportunities: | Research Projects - Thematic Grants |