Integrative perspective of the healthy aging process considering the metabolome, cardiac autonomic modulation and cardiorespiratory fitness evaluated in age groups

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De Favari Signini, Etore ; Castro, Alex ; Rehder-Santos, Patricia ; Cristina Millan-Mattos, Juliana ; Magalhaes de Oliveira, Juliana ; Minatel, Vinicius ; Bianca Falasco Pantoni, Camila ; Sobreiro Selistre de Araujo, Heloisa ; Fabrizzi, Fernando ; Porta, Alberto ; Gilberto Ferreira, Antonio ; Vincenzi Oliveira, Regina ; Maria Catai, Aparecida

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 12, n. 1, p. 12-pg., 2022-12-09.

Abstract

The aging process causes changes at all organic levels. Although metabolism, cardiac autonomic modulation (CAM), and cardiorespiratory fitness (CRF) are widely studied as a function of age, they are mainly studied in isolation, thus making it difficult to perceive their concomitant variations. This study aimed to investigate the integrated changes that occur in the metabolome, CAM, and CRF throughout aging in apparently healthy individuals. The subjects (n=118) were divided into five groups according to age (20-29, 30-39, 40-49, 50-59, and 60-70 years old) and underwent blood collection, autonomic assessment, and a cardiopulmonary exercise test for metabolomics analysis using mass spectrometry and nuclear magnetic resonance, cardiac autonomic modulation analysis, and CRF by peak oxygen consumption analysis, respectively. The Tukey's post hoc and effect size with confidence interval were used for variables with a significant one-way ANOVA effect (P<0.01). The main changes were in the oldest age group, where the CRF, valine, leucine, isoleucine, 3-hydroxyisobutyrate, and CAM reduced and hippuric acid increased. The results suggest significant changes in the metabolome, CAM, and CRF after the age of sixty as a consequence of aging impairments, but with some changes in the metabolic profile that may be favorable to mitigate the aging deleterious effects. (AU)

• FAPESP's process: 10/52070-4 - New approaches for evaluation of cardiovascular oscillations changes with aging
• Grantee: Aparecida Maria Catai
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/13939-7 - Metabolomic analysis by Nuclear Magnetic Resonance (NMR) and mass spectrometry (LC-MS) of blood samples from individuals submitted to cardiorespiratory rehabilitation.
• Grantee: Alex Castro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/22215-7 - Impact of inspiratory muscle training and aging on metabolic mapping, autonomic modulation, and cardiovascular, respiratory and metabolic responses, and prediction of cardiorespiratory health through wearables
• Grantee: Aparecida Maria Catai
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/15040-4 - Omic-based strategies for the investigation of biomarkers for early diagnosis of patients with progressive biliary diseases
• Grantee: Juliana Magalhães de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/05965-8 - Metabolomic strategies based on LC-HRMS for investigation of potential biomarkers for clinical diagnosis - Phase I
• Grantee: Regina Vincenzi Oliveira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/25082-3 - Study of the metabolic profile in active and sedentary aging: metabolomic approach
• Grantee: Étore de Favari Signini
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)