| Full text | |
| Author(s): |
Polinario, Giulia
;
Primo, Laura Maria Duran Gleriani
;
Rosa, Maiara Alane Baraldi Cerquetani
;
Dett, Freddy Humberto Marin
;
Barbugli, Paula Aboud
;
Roque-Borda, Cesar Augusto
;
Pavan, Fernando Rogerio
Total Authors: 7
|
| Document type: | Journal article |
| Source: | FRONTIERS IN MICROBIOLOGY; v. 14, p. 17-pg., 2023-06-02. |
| Abstract | |
Tuberculosis and lung cancer are, in many cases, correlated diseases that can be confused because they have similar symptoms. Many meta-analyses have proven that there is a greater chance of developing lung cancer in patients who have active pulmonary tuberculosis. It is, therefore, important to monitor the patient for a long time after recovery and search for combined therapies that can treat both diseases, as well as face the great problem of drug resistance. Peptides are molecules derived from the breakdown of proteins, and the membranolytic class is already being studied. It has been proposed that these molecules destabilize cellular homeostasis, performing a dual antimicrobial and anticancer function and offering several possibilities of adaptation for adequate delivery and action. In this review, we focus on two important reason for the use of multifunctional peptides or peptides, namely the double activity and no harmful effects on humans. We review some of the main antimicrobial and anti-inflammatory bioactive peptides and highlight four that have anti-tuberculosis and anti-cancer activity, which may contribute to obtaining drugs with this dual functionality. (AU) | |
| FAPESP's process: | 22/09728-6 - Evaluation of the against resistant Mycobacterium tuberculosis activity of N-acetylcysteine-chitosan nanoparticles conjugated with the antimicrobial peptide Ctx(Ile21)-Ha-Ahx-Cys loaded with rifampicin. |
| Grantee: | Laura Maria Duran Gleriani Primo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 20/16573-3 - In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis |
| Grantee: | Cesar Augusto Roque Borda |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 20/13497-4 - Search for the mechanism of action and therapeutic effect of new classes of drugs against Mycobacterium tuberculosis |
| Grantee: | Fernando Rogério Pavan |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/14603-5 - Drug discovery and design: antimicrobial peptide B1CTcu5 analogs promising against Mycobacterium tuberculosis |
| Grantee: | Cesar Augusto Roque Borda |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |