Hybrid lipid-biopolymer nanocarrier as a strategy for GBM photodynamic therapy (PDT)

Author(s)

Barbosa, Hellen Franciane Goncalves ; Piva, Henrique Luis ; Matsuo, Flavia Sayuri ; de Lima, Sarah Caroline Gomes ; de Souza, Lucas Eduardo Botelho ; Osako, Mariana Kiomy ; Tedesco, Antonio Claudio

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 242, p. 14-pg., 2023-05-08.

Abstract

Glioblastoma (GBM) is the most common brain cancer characterized by aggressive and infiltrated tumors. For this, hybrid biopolymer-lipid nanoparticles coated with biopolymers such as chitosan and lipidic nanocarriers (LN) loaded with a photosensitizer (AlClPc) can be used for GBM photodynamic therapy. The chitosan-coated LN exhibited stable physicochemical characteristics and presented as an excellent lipid nanocarrier with highly efficiently encapsulated photosensitizer chloro-aluminum phthalocyanine (AlClPc). LN(AlClPc)Ct0.1% in the presence of light produced more reactive oxygen species and reduced brain tumor cell viability and proliferation. Confirm the effects of in vivo LN applications with photodynamic therapy confirmed that the total brain tumor area decreased without systemic toxicity in mice. These results suggest a promising strategy for future clinical applications to improve brain cancer treatment. (AU)

• FAPESP's process: 18/17911-0 - Lipid nanocarrier covered with polymer applied to the diagnosis and treatment of pathologies from central nervous system by intranasal delivery of therapeutic agents
• Grantee: Hellen Franciane Gonçalves Barbosa
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/50181-1 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders
• Grantee: Antonio Claudio Tedesco
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/04009-6 - Development of a novel bioink for 3D printing scaffolds for regeneration of cartilage tissues
• Grantee: Henrique Luis Piva
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)