| Full text | |
| Author(s): Show less - |
Trettel, Caio dos Santos
;
Pelozin, Bruno Rocha de Avila
;
Barros, Marcelo Paes
;
Bachi, Andre Luis Lacerda
;
Braga, Pedro Gabriel Senger
;
Momesso, Cesar Miguel
;
Furtado, Guilherme Eustaquio
;
Valente, Pedro Afonso
;
Oliveira, Edilamar Menezes
;
Hogervorst, Eef
;
Fernandes, Tiago
Total Authors: 11
|
| Document type: | Journal article |
| Source: | FRONTIERS IN ENDOCRINOLOGY; v. 14, p. 9-pg., 2023-02-10. |
| Abstract | |
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging. (AU) | |
| FAPESP's process: | 17/06032-2 - Biochemical, physiological and transcriptomic strategies to study the relationship between carotenoids, oxidative stress and Citrus fruit quality |
| Grantee: | Marcelo Paes de Barros |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 15/17275-8 - Role of microRNA-205 in the angiogenic deficit mediated by FAK signaling in hypertension: effect of exercise training and perspective of the therapeutic potential |
| Grantee: | Tiago Fernandes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 22/03138-2 - Functions and regulatory mechanisms of lincRNA-p21 in skeletal muscle: role on stem cell fate, myogenesis, trophism, contractility, exercise performance and injury repair |
| Grantee: | Tiago Fernandes |
| Support Opportunities: | Research Grants - Initial Project |