| Full text | |
| Author(s): Show less - |
Correia, Banny Silva Barbosa
;
Pontes, Joao Guilherme de Moraes
;
Nani, Joao Victor Silva
;
Villalta, Fabian
;
Mor, Natalia Cristina
;
Bordini, Daniela
;
Brunoni, Decio
;
Brentani, Helena
;
Mari, Jair Jesus
;
Hayashi, Mirian A. F.
;
Tasic, Ljubica
Total Authors: 11
|
| Document type: | Journal article |
| Source: | ACS Chemical Neuroscience; v. 14, n. 6, p. 9-pg., 2023-02-21. |
| Abstract | |
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by patients displaying at least two out of the classical symptoms, such as impaired social communication, impaired interactions, and restricted repeti t i v e behavior. Early parent-mediated interventions, such as video modeling for parental training, were demonstrated to be a successf u l low-cost way to del i v e r care for children with ASD. Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been success-fully employed in several mental disorder studies. Metabolomics and lipidomics of 37 ASD patients (children, aged 3-8 years), who were divided into two groups, one control group with no parental-training intervention (N = 18) and the other in which the parents were trained by a video modeling intervention (ASD parental training, N = 19), were analyzed by proton NMR spectroscopy. Patients in the ASD parental-training group sera were seen to have increased glucose, myo-inositol, malonate, prol i n e , phenylalanine, and gangliosides in their blood ser u m , while cholesterol, choline, and lipids were decreased, compared to the control group, who received no parental-training. Taken together, we demonstrated here significant changes in serum metabolites and lipids in ASD children, previously demonstrated to show clinical positive efl'ects following a parental training intervention based on video modeling, delivered over 22 weeks. We demonstrate the value of applying metabolomics and lipidomics to identify potential biomarkers for clinical interventions follow-up in ASD. (AU) | |
| FAPESP's process: | 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders |
| Grantee: | João Victor Silva Nani |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/13112-8 - Study of molecular and cellular mechanisms involved in mental disorders: clinical and animal models analysis |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/01107-7 - Study to optimize the use of crotamine as a theranostic in the therapy of human diseases: cancer, metabolic syndrome and renal dysfunction |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |