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1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study

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Correia, Banny Silva Barbosa ; Pontes, Joao Guilherme de Moraes ; Nani, Joao Victor Silva ; Villalta, Fabian ; Mor, Natalia Cristina ; Bordini, Daniela ; Brunoni, Decio ; Brentani, Helena ; Mari, Jair Jesus ; Hayashi, Mirian A. F. ; Tasic, Ljubica
Total Authors: 11
Document type: Journal article
Source: ACS Chemical Neuroscience; v. 14, n. 6, p. 9-pg., 2023-02-21.
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by patients displaying at least two out of the classical symptoms, such as impaired social communication, impaired interactions, and restricted repeti t i v e behavior. Early parent-mediated interventions, such as video modeling for parental training, were demonstrated to be a successf u l low-cost way to del i v e r care for children with ASD. Nuclear magnetic resonance (NMR)-based metabolomics/lipidomics has been success-fully employed in several mental disorder studies. Metabolomics and lipidomics of 37 ASD patients (children, aged 3-8 years), who were divided into two groups, one control group with no parental-training intervention (N = 18) and the other in which the parents were trained by a video modeling intervention (ASD parental training, N = 19), were analyzed by proton NMR spectroscopy. Patients in the ASD parental-training group sera were seen to have increased glucose, myo-inositol, malonate, prol i n e , phenylalanine, and gangliosides in their blood ser u m , while cholesterol, choline, and lipids were decreased, compared to the control group, who received no parental-training. Taken together, we demonstrated here significant changes in serum metabolites and lipids in ASD children, previously demonstrated to show clinical positive efl'ects following a parental training intervention based on video modeling, delivered over 22 weeks. We demonstrate the value of applying metabolomics and lipidomics to identify potential biomarkers for clinical interventions follow-up in ASD. (AU)

FAPESP's process: 19/09207-3 - Study of molecular and cellular mechanisms in mental disorders
Grantee:João Victor Silva Nani
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
Grantee:Fernando Barbosa Júnior
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/13112-8 - Study of molecular and cellular mechanisms involved in mental disorders: clinical and animal models analysis
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/01107-7 - Study to optimize the use of crotamine as a theranostic in the therapy of human diseases: cancer, metabolic syndrome and renal dysfunction
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Regular Research Grants