Mantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases

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Ribeiro Carvalho, Marcus Vinicius ; Rodrigues-Fernandes, Carla Isabelly ; Lopez de Caceres, Cinthia Veronica Bardalez ; Mesquita, Ricardo Alves ; Martins, Manoela Domingues ; Jose Roman Tager, Elena Maria ; Carlos, Roman ; Pires, Fabio Ramoa ; Robinson, Liam ; van Heerden, Willie F. P. ; Valente, Vitor Bonetti ; Caldeira Xavier-Junior, Jose Candido ; Bernabe, Daniel Galera ; Rebelo Pontes, Helder Antonio ; Soares, Ciro Dantas ; Melo da Costa, Mauro Henrique ; Vargas, Pablo Agustin ; Fonseca, Felipe Paiva

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 135, n. 1, p. 9-pg., 2023-01-01.

Abstract

Objective. To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. Methods. The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis. Clinical data of the cases were obtained from the patients' pathosis and/or medical charts. Results. Twenty cases were included in the study, showing a male predominance and a mean age of 66 years. The oral cavity (12 cases) and the oropharynx (5 cases) were the most commonly involved subsites. Most cases presented as asymptomatic swellings, with 2 cases showing bilateral involvement of the palate. The classic histologic variant predominated (12/20 cases). All cases expressed CD20 with nuclear cyclin D1 positivity. SOX11 was seen in 9/13 cases, CD5 in 6/16 cases, Bcl2 in 16/19 cases, CD10 in 2/20 cases, and Bcl6 in 4/16 cases. Ki67 showed a mean proliferation index of 40.6%. The Epstein-Barr virus (EBV) was negative in all cases investigated. Follow-up data was available for 7 patients, with 5 currently alive and 2 deceased. Conclusion. Mantle cell lymphoma, albeit rare, may manifest in the oral and maxillofacial region. Its histologic heterogeneity demands a high degree of diagnostic skill from pathologists. (Oral Surg Oral Med Oral Pathol Oral Radiol 2023;135:101-109) (AU)

• FAPESP's process: 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity
• Grantee: Oslei Paes de Almeida
• Support Opportunities: Regular Research Grants