A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Author(s)

Vieira, Eduardo Guimaraes ; Fazzi, Rodrigo Boni ; Martins, Daniel O. T. A. ; Sheveleva, Alena M. ; Tuna, Floriana ; Ferreira, Ana Maria da Costa

• Document type: Journal article
• Source: RSC ADVANCES; v. 13, n. 14, p. 5-pg., 2023-03-20.

Abstract

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials. (AU)

• FAPESP's process: 17/21919-3 - Spectroscopic and magnetic characterization of metallo-pharmaceuticals immobilized in hybrid matrices for drug delivery
• Grantee: Eduardo Guimarães Vieira
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 16/16735-8 - Imobilization of potential metallopharmaceuticals in inorganic and organic matrices for modified delivery
• Grantee: Eduardo Guimarães Vieira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/50342-3 - Advanced EPR spectroscopy applied to mechanistic studies on metallodrugs-biomolecules interactions
• Grantee: Ana Maria da Costa Ferreira
• Support Opportunities: Regular Research Grants