Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release

Author(s)

Tundisi, Louise Lacalendola ; Ataide, Janaina Artem ; da Fonseca, Jessica Heline Lopes ; Silverio, Luiza Aparecida Luna ; Lancellotti, Marcelo ; Paiva-Santos, Ana Claudia ; d'Avila, Marcos Akira ; Kohane, Daniel S. ; Mazzola, Priscila Gava

• Document type: Journal article
• Source: PHARMACEUTICS; v. 15, n. 3, p. 16-pg., 2023-03-01.

Abstract

A poloxamer 407 (P407)-Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamer-casein hydrogel in a different addition order to evaluate the effect of gel formation. Nanoparticles were prepared by the nanoprecipitation technique and characterized by evaluating their physicochemical characteristics and morphology. The nanoparticles had a mean diameter of 196.7 +/- 0.7 nm, PDI of 0.07, negative zeta potential (-0.713 mV), high encapsulation efficiency (>98%), and did not show cytotoxic effects in primary human keratinocytes. PCL-NP modulated terbinafine was released in artificial sweat. Rheological properties were analyzed by temperature sweep tests at different addition orders of nanoparticles into hydrogel formation. The rheological behavior of nanohybrid hydrogels showed the influence of TBH-PCL nanoparticles addition in the mechanical properties of the hydrogel and a long-term release of the nanoparticles from it. (AU)

• FAPESP's process: 18/06475-4 - Development of pharmaceutical formulation for burns' healing
• Grantee: Janaína Artem Ataide
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/10728-2 - Encapsulation and surface modulation with polycaprolactone (PCL): a novel approach for the treatment of topical fungal infections
• Grantee: Louise Lacalendola Tundisi
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/07707-6 - Development of formulation for burns: analgesia, infection control and healing
• Grantee: Priscila Gava Mazzola
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/05421-8 - "Encapsulation and surface modulation with polycaprolactone (PCL): seeking a dermal drug-delivery modification"
• Grantee: Louise Lacalendola Tundisi
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate