Topical route brings many advantages over oral treatment, since there is no first-pass effect, no drug interactions and usually does not require laboratory monitoring during treatment. On the other hand, it still brings patients some difficulties related mainly to patient compliance once the treatment is long, inconvenient and demanding, which can lead to failure in the treatment. As an improvement in topical drug delivery effectiveness, the investigation of new pharmaceutical formulation is mandatory for increasing patient compliance, by easing the therapeutic regime. In this context, the aim of this proposal is to investigate the modulation of polymeric nanoparticles to modify its release, helping the improvement of patient compliance by manly reducing drug administration times. Modified drug release by polymer systems increases drug efficacy and may lead to decreased dosage and number of daily administrations, maximizing patient compliance and treatment success. Modified release can be controlled by different mechanisms such as: modulation of the particle surface, modification in the polymeric design and use of a stimulus-responsive polymer already established. These mechanisms will be studied to choose the one that suits better topical modify drug release, starting with polymer design modification in order to make a redox responsive biopolymer.
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