Organoids as a novel tool in modelling infectious diseases

Author(s):Show less -

de Oliveira, Lucas Felipe ; Mendes Filho, Daniel ; Marques, Bruno Lemes ; Maciel, Giovana Figueiredo ; Parreira, Ricardo Cambraia ; Neto, Jose Rodrigues do Carmo ; Da Silva, Priscilla Elias Ferreira ; Guerra, Rhanoica Oliveira ; da Silva, Marcos Vinicius ; Santiago, Helton da Costa ; Birbrair, Alexander ; Kihara, Alexandre H. ; da Silva, Valdo Jose Dias ; Glaser, Talita ; Resende, Rodrigo R. ; Ulrich, Henning

• Document type: Journal article
• Source: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; v. 144, p. 10-pg., 2023-03-17.

Abstract

Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue ar-chitecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host-infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments. (AU)

• FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
• Grantee: Alexander Henning Ulrich
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/11667-0 - Cellular and electrophysiological changes in the hippocampus caused by neurodegenerative processes related to neonatal anoxia and temporal lobe epilepsy
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants