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Holmium-doped 58S glass-derived foam-like scaffolds

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Author(s):
Baino, Francesco ; Marchi, Juliana ; Borges, Roger ; Verne, Enrica
Total Authors: 4
Document type: Journal article
Source: Materials Letters; v. 341, p. 3-pg., 2023-03-22.
Abstract

Biocompatible implantable glasses doped with rare earth elements (e.g. holmium) are regarded as promising biomaterials for advanced medical therapies. In this work, Ho-containing scaffolds based on the 58S sol-gel glass composition were fabricated for the first time through sponge replication followed by sinter-crystallization, which was associated to the formation of CaSiO3. The obtained materials exhibited high porosity (86 vol%), trabecular pore-strut 3D architecture and compressive strength (around 1 MPa) comparable to that of osseous tissue, making them promising candidates for use in bone applications. (AU)

FAPESP's process: 20/00329-6 - Development of a multifunctional injectable composite aiming bone cancer treatment through hyperthermia and brachytherapy allied with bone repair
Grantee:Juliana Marchi
Support Opportunities: Regular Research Grants