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Current Applications of Liposomes for the Delivery of Vitamins: A Systematic Review

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Author(s):
Chaves, Matheus A. ; Ferreira, Leticia S. ; Baldino, Lucia ; Pinho, Samantha C. ; Reverchon, Ernesto
Total Authors: 5
Document type: Journal article
Source: NANOMATERIALS; v. 13, n. 9, p. 37-pg., 2023-05-05.
Abstract

Liposomes have been used for several decades for the encapsulation of drugs and bioactives in cosmetics and cosmeceuticals. On the other hand, the use of these phospholipid vesicles in food applications is more recent and is increasing significantly in the last ten years. Although in different stages of technological maturity-in the case of cosmetics, many products are on the market-processes to obtain liposomes suitable for the encapsulation and delivery of bioactives are highly expensive, especially those aiming at scaling up. Among the bioactives proposed for cosmetics and food applications, vitamins are the most frequently used. Despite the differences between the administration routes (oral for food and mainly dermal for cosmetics), some challenges are very similar (e.g., stability, bioactive load, average size, increase in drug bioaccessibility and bioavailability). In the present work, a systematic review of the technological advancements in the nanoencapsulation of vitamins using liposomes and related processes was performed; challenges and future perspectives were also discussed in order to underline the advantages of these drug-loaded biocompatible nanocarriers for cosmetics and food applications. (AU)

FAPESP's process: 22/01236-7 - Hybrid and synthetic vesicles formed by extracellular vesicles and liposomes for the supplementation of embryo cells during bovine in vitro production
Grantee:Matheus Andrade Chaves
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/08345-3 - Supercritical assisted process for the coencapsulation of curcumin and vitamin D3 into liposomes
Grantee:Matheus Andrade Chaves
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/10954-2 - Enrichment of cornstarch with curcumin and Vitamin D3 coencapsulated in lyophilized liposomes using wet agglomeration by high shear
Grantee:Matheus Andrade Chaves
Support Opportunities: Scholarships in Brazil - Doctorate