Role of Gasotransmitters in Inflammatory Edema

Author(s)

Coavoy-Sanchez, Silvia Abigail ; Marques, Leonardo Andre da Costa ; Costa, Soraia Katia Pereira ; Muscara, Marcelo Nicolas

• Document type: Journal article
• Source: Antioxidants & Redox Signaling; v. N/A, p. 20-pg., 2023-05-23.

Abstract

Significance: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are, to date, the identified members of the gasotransmitter family, which consists of gaseous signaling molecules that play central roles in the regulation of a wide variety of physiological and pathophysiological processes, including inflammatory edema. Recent Advances: Recent studies show the potential anti-inflammatory and antiedematogenic effects of NO-, CO-, and H2S-donors in vivo. In general, it has been observed that the therapeutical effects of NO-donors are more relevant when administered at low doses at the onset of the inflammatory process. Regarding CO-donors, their antiedematogenic effects are mainly associated with inhibition of proinflammatory mediators (such as inducible NO synthase [iNOS]-derived NO), and the observed protective effects of H2S-donors seem to be mediated by reducing some proinflammatory enzyme activities. Critical Issues: The most recent investigations focus on the interactions among the gasotransmitters under different pathophysiological conditions. However, the biochemical/pharmacological nature of these interactions is neither general nor fully understood, although specifically dependent on the site where the inflammatory edema occurs. Future Directions: Considering the nature of the involved mechanisms, a deeper knowledge of the interactions among the gasotransmitters is mandatory. In addition, the development of new pharmacological tools, either donors or synthesis inhibitors of the three gasotransmitters, will certainly aid the basic investigations and open new strategies for the therapeutic treatment of inflammatory edema. (AU)

• FAPESP's process: 13/04151-3 - Pharmacological evaluation of sulfide hydrogen donors (rapid and slow release) in pruritus and related inflammation in mice skin
• Grantee: Soraia Katia Pereira Costa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/24518-1 - Role of hydrogen sulfide (H2S) in the inflammatory and nociceptive responses induced by carrageenan in the rat temporomandibular joint
• Grantee: Marcelo Nicolas Muscara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/16409-6 - Effect of hydrogen sulfide (H2S) donors on experimental atopic dermatitis in mice.
• Grantee: Silvia Abigail Coavoy Sanchez
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/14051-2 - Study on the participation and effects of hydrogen sulfide (H2S) on the in vitro vasomotor response of mouse mesenteric artery
• Grantee: Marcelo Nicolas Muscara
• Support Opportunities: Regular Research Grants