Synthesis of 5 '-seleno-xylofuranosides

Author(s)

Braga, Hugo C. ; Stefani, Helio A. ; Paixao, Marcio W. ; Santos, Francielli W. ; Luedtke, Diogo S.

• Document type: Journal article
• Source: Tetrahedron; v. 66, n. 19, p. 6-pg., 2010-05-08.

Abstract

The synthesis of selenium derivatives of naturally occurring chiral molecules is becoming increasingly important in recent years. In this context, we describe herein an easy, straightforward synthetic route for the preparation of a series of chiral seleno-furanosides, starting from the readily available carbohydrate D-xylose. In addition, selected compounds were screened as inhibitors of the delta-aminolevulinate dehyclratase (delta-ALA-D) enzyme. Diselenide 4 was found to reduce significantly the enzymatic activity, while seleno-furanoside la increased delta-ALA-D activity. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 07/02382-7 - Carbohydrates as a chiral pool in organic synthesis: applications in asymmetric catalysis and synthesis of glycopeptides with potential biological activity
• Grantee: Diogo Seibert Lüdtke
• Support Opportunities: Regular Research Grants