| Full text | |
| Author(s): |
Higuchi, C. T.
;
Sannomiya, M.
;
Pavan, F. R.
;
Leite, S. R. A.
;
Sato, D. N.
;
Franzblau, S. G.
;
Sacramento, L. V. S.
;
Vilegas, W.
;
Leite, C. Q. F.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Evidence-based Complementary and Alternative Medicine; v. 2011, p. 5-pg., 2011-01-01. |
| Abstract | |
Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK). (AU) | |
| FAPESP's process: | 02/05503-6 - Sustainable use of the Brazilian biodiversity: chemical and pharmacological prospection on higher plants |
| Grantee: | Wagner Vilegas |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |