| Full text | |
| Author(s): Show less - |
de Souza Pinhel, Marcelo Augusta
;
Sado, Caroline Leiko
;
Longo, Gabriela dos Santos
;
Gregorio, Michele Limo
;
Amorim, Gisele Sousa
;
da Silva Florim, Greiciane Maria
;
Mazeti, Camila Montoro
;
Martins, Denise Poltronieri
;
Oliveira, Fabio de Nazare
;
Nakozone, Marcelo Arruda
;
Tognola, Waldir Antonio
;
Silva Souza, Doroteia Rossi
Total Authors: 12
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 71, n. 8, p. 6-pg., 2013-08-01. |
| Abstract | |
Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the chi(2) test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1. (AU) | |
| FAPESP's process: | 09/18476-6 - Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
| Grantee: | Caroline Leiko Sado |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |