Chronic Inflammation and Neutrophil Activation as Possible Causes of Joint Diseases in Ballet Dancers

Author(s)

Borges, Leandro da Silva ; Bortolon, Jose Ricardo ; Santos, Vinicius Coneglian ; de Moura, Nivaldo Ribeiro ; Dermargos, Alexandre ; Cury-Boaventura, Maria Fernanda ; Gorjao, Renata ; Pithon-Curi, Tania Cristina ; Hatanaka, Elaine

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2014, p. 7-pg., 2014-01-01.

Abstract

Herein, we investigated the effects of a ballet class on the kinetic profiles of creatine kinase (CK) and lactate dehydrogenase (LDH) activities, cytokines, complement component 3 (C3), and the concentrations of immunoglobulin (Ig), IgA and IgM, in ballerinas. We also verified neutrophil death and ROS release. Blood samples were taken from 13 dancers before, immediately after, and 18 hours after a ballet class. The ballet class increased the plasma activities of CK-total (2.0-fold) immediately after class, while the activities of CK-cardiac muscle (1.0-fold) and LDH (3.0-fold) were observed to increase 18 hours after the class. Levels of the TNF-alpha, IL-1 beta, IgG, and IgA were not affected under the study conditions. The exercise was found to induce neutrophil apoptosis (6.0-fold) 18 hours after the ballet class. Additionally, immediately after the ballet class, the neutrophils from the ballerinas were found to be less responsive to PMA stimulus. Conclusion. Ballet class was found to result in inflammation in dancers. The inflammation caused by the ballet class remained for 18 hours after the exercise. These findings are important in preventing the development of chronic lesions that are commonly observed in dancers, such as those with arthritis and synovitis. (AU)

• FAPESP's process: 10/04005-9 - Installation and resolution of the inflammatory process in classic dancers: study of the systemic and leukocytary alterations
• Grantee: Leandro da Silva Borges
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 11/21441-0 - Time course of the inflammatory process in classical ballet dancers: leukocytes and systemic alterations
• Grantee: Elaine Hatanaka Dermargos
• Support Opportunities: Regular Research Grants