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Effect of Low-Level Laser on Bone Defects Treated with Bovine or Autogenous Bone Grafts: In Vivo Study in Rat Calvaria

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Author(s):
Cunha, Mercia J. S. ; Esper, Luis A. ; Sbrana, Michyele C. ; de Oliveira, Paula G. F. P. ; do Valle, Accacio L. ; de Almeida, Ana Lucia P. F.
Total Authors: 6
Document type: Journal article
Source: BIOMED RESEARCH INTERNATIONAL; v. 2014, p. 9-pg., 2014-01-01.
Abstract

Objective. The purpose of this study was to histologically evaluate the effect of low-level laser (LLL) on the healing of critical size defects (CSD) in rat calvaria, filled with autogenous or inorganic bovine bone grafts. Methods. Sixty rats were divided into 6 groups (n = 10): C (control-filled with blood clot), LLL (low-level laser-GaAlAs, lambda 780 nm, 100 mW, 210 J/cm(2), Phi 0.05 cm(2); 6 J/point), AB (autogenous bone), ABL (autogenous bone + low-level laser), OB (inorganic bovine bone), and OBL (inorganic bovine bone + LLL). Material and Methods. The animals were killed after 30 days. Histological and histometric analyses were performed by light microscopy. Results. The groups irradiated with laser, LLL (47.67% +/- 8.66%), ABL (39.15% +/- 16.72%), and OBL (48.57% +/- 28.22%), presented greater area of new bone formation than groups C (9.96% +/- 4.50%), AB (30.98% +/- 16.59%), and OB (11.36% +/- 7.89%), which were not irradiated. Moreover, they were significantly better than group C (Kruskal-Wallis test followed by Dunn test, P < 0.05). Conclusion. The laser accelerated the healing of bone defects and the resorption of particles of the graft material. (AU)

FAPESP's process: 10/10538-0 - Analysis of healing of surgically created bone defects in rat calvaria treated with bovine grafts (Bio-Oss) associated with low level laser: histological and histometric study
Grantee:Ana Lucia Pompeia Fraga de Almeida
Support Opportunities: Regular Research Grants
FAPESP's process: 10/13170-3 - Analysis of healing of surgically created bone defects in rat calvaria treated with bovine grafts (Bio-Oss) associated with low level laser. Histological and histometric study
Grantee:Mércia Jussara da Silva Cunha
Support Opportunities: Scholarships in Brazil - Master