Compatibility of Cassava Starch Films as Nitric Oxide Carrier for Potential Medical Device

Author(s)

Aguiar, Helena de Fazio ; Roveda Junior, Antonio Carlos ; Piva, Renan de Jesus ; Onoda, Kevin Akira ; Miyakawa, Ayumi Aurea ; Krieger, Jose Eduardo ; Franco, Douglas Wagner ; Tadini, Carmen Cecilia

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 132, n. 2, p. 10-pg., 2015-01-10.

Abstract

Films prepared with bioabsorbable materials (cassava starch, glycerol, and carboxymethyl cellulose (CMC)) can be used as an external support in the myocardial revascularization surgery, releasing nitric oxide (NO) during the tissue regeneration. In the present study, these materials submitted to in vitro degradation tests under physiological conditions, presented the reduction of 38% of weight loss by the modification of native starch using sodium trimetaphosphate (STMP) (15 g/100g of starch). The CMC addition of 10 g/100g of cassava starch increased 119% of the tensile strength of the films in comparison with films prepared without CMC. It was verified that the ruthenium complex trans-[Ru(NH3)(4)(isn)(NO)](BF4)(3) incorporated in the starch based films behave similarly as in aqueous solution, releasing NO by photochemical reaction. Macrophage cells were detected in in vivo degradation tests in rats around the implant after 1 and 7 days, and complete biodegradation was observed after 30 days. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41382. (AU)

• FAPESP's process: 12/23651-4 - Nitrosyl and nitroxyl as ligands on Ru(II): synthesis, kinetics, reactivity and thermodynamics
• Grantee: Douglas Wagner Franco
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/16057-3 - Study of biodegration of films based on cassava starch for potential medical application
• Grantee: Renan de Jesus Piva
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther
• Grantee: José Eduardo Krieger
• Support Opportunities: Research Projects - Thematic Grants