| Full text | |
| Author(s): |
Santana, Fernanda Paula R.
;
Pinheiro, Nathalia M.
;
Mernak, Marcia Isabel B.
;
Righetti, Renato F.
;
Martins, Milton A.
;
Lago, Joao H. G.
;
dos Santos Lopes, Fernanda D. T. Q.
;
Tiberio, Iolanda F. L. C.
;
Prado, Carla M.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Mediators of Inflammation; v. 2016, p. 14-pg., 2016-01-01. |
| Abstract | |
Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action. (AU) | |
| FAPESP's process: | 10/14831-3 - Effects of flavonoids derived from Baccharis retusa treatment in a model of ovalbumin-induce chronic allergic pulmonary inflammation induced in mice |
| Grantee: | Camila Pivari Pedroso Sakoda |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 11/15817-7 - CHOLINERGIC HYPOFUNCTION EFFECTS IN THE MECHANICAL AND LUNG HISTOPATHOLOGY IN AN EXPERIMENTAL MODEL OF LUNG INFLAMMATION INDUCED BY AIR POLLUTANT INSTILLATION IN MICE |
| Grantee: | Fernanda Paula Roncon Santana Novelli |
| Support Opportunities: | Scholarships in Brazil - Master |