Singlet molecular oxygen: Dusseldorf - Sao Paulo, the Brazilian connection

Author(s)

Di Mascio, Paolo ; Martinez, Glaucia R. ; Miyamoto, Sayuri ; Ronsein, Graziella E. ; Medeiros, Marisa H. G. ; Cadet, Jean

• Document type: Journal article
• Source: Archives of Biochemistry and Biophysics; v. 595, p. 15-pg., 2016-04-02.

Abstract

Inspired by Helmut Sies we continue the development of suitable chemical generators of O-1(2) based on the thermodissociation of naphthalene endoperoxide derivatives. The present manuscript focuses on how the use of [O-18] -labeled endoperoxides and hydroperoxides can be applied to study mechanistic aspects related to the generation of singlet molecular oxygen and its reactions in biological systems. The peroxidation reactions of the main cellular targets including unsaturated lipids, proteins and nucleic acids have received major attention during the last three decades. Emphasis is placed in this manuscript on the description of the synthesis and the main use of [O-18]-labeled compounds, and especially of peroxides and O-1(2), for tracer elucidation of reaction mechanisms. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 12/12663-1 - Singlet molecular oxygen and peroxides in chemical biology
• Grantee: Paolo Di Mascio
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 11/10048-5 - Mapping adducts generated by endogenous and exogenous aldehydes: use as biomarkers of redox stress
• Grantee: Marisa Helena Gennari de Medeiros
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC