Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche

Author(s)

Chang, Eun Hyuk ; Adorjan, Istvan ; Mundim, Mayara V. ; Sun, Bin ; Dizon, Maria L. V. ; Szele, Francis G.

• Document type: Journal article
• Source: FRONTIERS IN NEUROSCIENCE; v. 10, p. 14-pg., 2016-08-02.

Abstract

Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI. (AU)

• FAPESP's process: 14/00927-0 - Role of galectin-3 in neuroblast migration in a traumatic brain injury model
• Grantee: Mayara Terra Villela Vieira Mundim
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 12/06810-1 - Molecular mechanisms involved in the determination of migratory neuroblasts destiny
• Grantee: Mayara Terra Villela Vieira Mundim
• Support Opportunities: Scholarships in Brazil - Doctorate