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Role of galectin-3 in neuroblast migration in a traumatic brain injury model

Grant number: 14/00927-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 19, 2014
Effective date (End): April 25, 2015
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Marimélia Aparecida Porcionatto
Grantee:Mayara Terra Villela Vieira Mundim
Supervisor abroad: Francis George Szele
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: University of Oxford, England  
Associated to the scholarship:12/06810-1 - Molecular mechanisms involved in the determination of migratory neuroblasts destiny, BP.DR

Abstract

There are two main neurogenic areas in the central nervous system of adult mammals: the subgranular zone of the dentate gyrus of hippocampus, which produces neural stem cells that differentiate into neurons that integrate the hippocampus, and the subventricular zone (SVZ) of the lateral ventricle, in which neural stem cells give rise to neuroblasts that migrate to the olfactory bulb, where they differentiate into interneurons. In pathological conditions, SVZ-derived neuroblasts migrate to the injured area in an attempt to repair the cell population. This migration is thought to be guided by some soluble molecules secreted by cells near the injury. It was recently demonstrated that Galectin-3, which is necessary for the migration of neuroblasts to the olfactory bulb in healthy conditions, also participates of neurogenesis events in stroke and multiple sclerosis. Preliminary data showed that Gal-3 is also upregulated in TBI, so our main question is how does Gal-3 regulates neurogenesis and migration of neuroblasts in TBI. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAMPRONI, LAURA N.; MUNDIM, MAYARA T. V. V.; PORCIONATTO, MARIMELIA A.. eurorepair and Regeneration of the Brain: A Decade of Bioscaffolds and Engineered Microtissu. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 09, . (14/23797-4, 18/12605-8, 12/06810-1, 14/00927-0, 13/16533-8)
CHANG, EUN HYUK; ADORJAN, ISTVAN; MUNDIM, MAYARA V.; SUN, BIN; DIZON, MARIA L. V.; SZELE, FRANCIS G.. Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet. FRONTIERS IN NEUROSCIENCE, v. 10, . (12/06810-1, 14/00927-0)

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