Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care

Author(s)

Yamane, Lais Thiemi ; de Paula, Eneida ; Jorge, Michelle Pedroza ; de Freitas-Blanco, Veronica Santana ; Montanari Junior, Ilio ; Figueira, Glyn Mara ; Anholeto, Luis Adriano ; de Oliveira, Patricia Rosa ; Ferreira Rodrigues, Rodney Alexandre

• Document type: Journal article
• Source: Evidence-based Complementary and Alternative Medicine; v. 2016, p. 9-pg., 2016-01-01.

Abstract

The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (+/- 28.5) min longer when compared with the positive control EMLA (R); the same occurred with the wound healing test; the film containing the highest concentration had a higherwound contraction (62.0%+/- 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment. (AU)

• FAPESP's process: 16/13776-5 - Acmella oleracea and Achyrocline satureioides as sources of natural products in topical wound care
• Grantee: Rodney Alexandre Ferreira Rodrigues
• Support Opportunities: Regular Research Grants - Publications - Scientific article