Intrauterine exposure to oestradiol promotes sex-specific differential effects on the prostatic development of neonate gerbils

Author(s)

Sanches, Bruno D. A. ; Maldarine, Juliana S. ; Biancardi, Manoel F. ; Santos, Fernanda C. A. ; Pinto-Fochi, Maria E. ; Antoniassi, Julia Q. ; Goes, Rejane M. ; Vilamaior, Patricia S. L. ; Taboga, Sebastiao R.

• Document type: Journal article
• Source: Cell Biology International; v. 41, n. 11, p. 10-pg., 2017-11-01.

Abstract

The effects of intrauterine exposure to 17 beta-oestradiol (E2) are well studied for the male prostate and there are accumulating evidences that the exposure to high dosages leads to a hypomorphic development. However, there is a lack of information about the effects of intrauterine exposure to E2 in the prostate of rodent females, and such research becomes relevant in view of the presence of functional prostate in a proportion of women, and the morphophysiological similarities between the prostate of female rodents and the prostate of women. This study uses histochemical, immunohistochemical, immunofluorescence and three-dimensional (3D) reconstruction techniques to evaluate the effects of intrauterine exposure to E2 (500 BW/d) on neonatal prostate development in both male and female gerbils. It was verified that intrauterine exposure to E2 promotes epithelial proliferation and growth of prostatic budding in females, whereas in males the prostatic budding shows hypomorphic growth in the VMP (Ventral Mesenchymal Pad) as well as reduced epithelial proliferation. Together, the data demonstrate that intrauterine exposure to E2 causes different effects on male and female prostates of the gerbil even at the early postnatal development of the gland. (AU)

• FAPESP's process: 13/16443-9 - Descriptive study of the branching process of Mongolian gerbil (Meriones unguiculatus) prostate ventral lobe
• Grantee: Bruno Casagrande Zani
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/15939-0 - Evaluation of intrauterine oestrogenic exposure on the main epithelium-mesenchyme interaction pathways in the branching morphogenesis in the Mongolian Gerbil prostrate ventral lobe
• Grantee: Bruno Domingos Azevedo Sanches
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)