Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biologicaleffects

Author(s)

Crisalli, Meredith A. ; Franco, Lilian P. ; Silva, Bruno R. ; Holanda, Alda K. M. ; Bendhack, Lusiane M. ; Da Silva, Roberto S. ; Ford, Peter C.

• Document type: Journal article
• Source: Journal of Coordination Chemistry; v. 71, n. 11-13, p. 14-pg., 2018-01-01.

Abstract

This research presents the synthesis and characterization of the photochemical nitric oxide (NO) precursor Ru(salenCO(2)H)(NO)Cl (1, salenCO(2)H=N,N'-ethylenebis(3,3'-bis-carboxylsalicylideneiminato). This water-soluble ruthenium nitrosyl releases NO upon photolysis with a quantum yield that is pH dependent owing to the nitrosyl to nitrite conversion of that axial ligand at higher pH. Also described are the water, oxygen, and thermal stability of 1 and the cytotoxicity and the vascular relaxivity properties of 1 in the dark and under photolysis. [GRAPHICS] . (AU)

• FAPESP's process: 16/12707-0 - Cytotoxicity and photo-cytotoxicity of new ruthenium-phthalocyanines compounds as nitric oxide and oxygen singlet producers in cancer cell lines. an innovative purpose for metal based drug
• Grantee: Roberto Santana da Silva
• Support Opportunities: Regular Research Grants