Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy

Author(s)

da Silveira Campos, Raquel Munhoz ; Landi Masquio, Deborah Cristina ; Corgosinho, Flavia Campos ; de Carvalho-Ferreira, Joana Pereira ; Netto, Barbara Dal Molin ; Grotti Clemente, Ana Paula ; Tock, Lian ; Tufik, Sergio ; de Mello, Marco Tulio ; Damaso, Ana Raimunda

• Document type: Journal article
• Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 62, n. 3, p. 10-pg., 2018-05-01.

Abstract

Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice. Arch Endocrinol Metab. 2018;62(3):275-84 (AU)

• FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
• Grantee: Raquel Munhoz da Silveira Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/19046-0 - Phototherapy and Physical Exercise: potential effects on the role of irisin and factores anorexigen and orexigen
• Grantee: Marcela Sene Fiorese
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants