Comparative genomics of pathogenic Leptospira interrogans serovar Canicola isolated from swine and human in Brazil

Author(s)

Moreno, Luisa Z. ; Miraglia, Fabiana ; Kremer, Frederico S. ; Eslabao, Marcus R. ; Dellagostin, Odir A. ; Lilenbaum, Walter ; Freitas, Julio C. ; Vasconcellos, Silvio A. ; Heinemann, Marcos B. ; Moreno, Andrea M.

• Document type: Journal article
• Source: Memórias do Instituto Oswaldo Cruz; v. 113, n. 2, p. 4-pg., 2018-02-01.

Abstract

Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health. Both human and porcine serovar Canicola isolates also presented sequences with high identity to the Chinese serovar Canicola published plasmids pGui1 and pGui2. The plasmids identification in the Brazilian and Chinese serovar Canicola strains suggest that extra-chromosomal elements are one more feature of this serovar that was previously unnoticed. (AU)

• FAPESP's process: 13/17136-2 - Characterization of Leptospira strains isolated in Brazil by pulsed field gel electrophoresis (PFGE) typing and comparative genomic analysis.
• Grantee: Luisa Zanolli Moreno
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/18290-0 - Characterization of Leptospira strains isolated in Brazil through multiloccus sequence typing (MLST)
• Grantee: Andrea Micke Moreno
• Support Opportunities: Regular Research Grants