| Full text | |
| Author(s): |
da Silveira Campos, Raquel Munhoz
;
Landi Masquio, Deborah Cristina
;
Corgosinho, Flavia Campos
;
Caranti, Danielle Arisa
;
Ganen, Aline de Piano
;
Tock, Lian
;
Oyama, Lila Missae
;
Damaso, Ana Raimunda
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Diabetes & Vascular Disease Research; v. 16, n. 2, p. 11-pg., 2019-03-01. |
| Abstract | |
Aim: To investigate the association between visceral adipose tissue loss and insulin resistance and hyperleptinemia in adolescents with obesity submitted to interdisciplinary weight-loss therapy. Methods: A total of 172 post-pubertal adolescents (body mass index greater than the 95th percentile of the Centers for Disease Control and Prevention reference growth charts) were recruited for the study. The adolescents were assigned to long-term weight-loss therapy. Body composition, visceral and subcutaneous fat, glucose metabolism, lipid profile, hepatic enzymes and leptin concentration were measured. After the therapy, the adolescents were allocated to three different groups according to the tertile of visceral fat reduction. Results: Positive effects on body composition were observed in all analysed groups independent of visceral fat reduction. It was found that visceral fat was an independent predictor of insulin resistance in the investigated population. Obese adolescents who lost a higher proportion of visceral adipose tissue (>1.8 cm) demonstrated improved metabolic and inflammatory parameters twice as much than those who presented smaller losses. Positive correlations between visceral fat reduction and glucose metabolism, lipid profile, hepatic enzymes and homeostasis model assessment of insulin resistance index were demonstrated. Conclusion: The magnitude of the reduction in visceral fat was an independent predictor of insulin resistance, hyperleptinemia and metabolic disorders related to obese adolescents. (AU) | |
| FAPESP's process: | 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women |
| Grantee: | Raquel Munhoz da Silveira Campos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process |
| Grantee: | Ana Raimunda Dâmaso |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/08522-6 - New therapeutic perspectives in obesity |
| Grantee: | Ana Raimunda Dâmaso |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents |
| Grantee: | Ana Raimunda Dâmaso |
| Support Opportunities: | Regular Research Grants |