| Full text | |
| Author(s): Show less - |
Sierra, Ana Paula
;
Oliveira-Junior, Manoel Carneiro
;
Almeida, Francine Maria
;
Benetti, Marino
;
Oliveira, Rodrigo
;
Felix, Soraia Nogueira
;
Genaro, Isabella Santos
;
Saraiva Romanholo, Beatriz Mangueira
;
Ghorayeb, Nabil
;
Peduti Dal Molin Kiss, Maria Augusta
;
Cury-Boaventura, Maria Fernanda
;
Pesquero, Joao Bosco
;
Vieira, Rodolfo Paula
Total Authors: 13
|
| Document type: | Journal article |
| Source: | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; v. 2019, p. 6-pg., 2019-01-01. |
| Abstract | |
Background. The endurance exercise is capable of inducing skeletal muscle, heart, and respiratory fatigue, evidenced by morphofunctional cardiac changes, release of myocardial injury biomarkers, and reduction of maximal voluntary ventilation and oxygen consumption (VO2) at peak exercise. Purpose. The aim of this study was to investigate whether marathoners present cardiac fatigue after marathon and whether it correlates with pulmonary levels of exhaled nitric oxide (eNO) and pulmonary inflammation. Methods. 31 male marathoners, age 39 +/- 9 years, were evaluated by cardiopulmonary exercise test three weeks before and between three and 15 days after a marathon; eNO analysis and spirometry were evaluated before, immediately after, and 24 and 72 hours after the marathon, and sputum cellularity and cytokine level were assessed before and after the marathon. Results. Marathon induced an increase in the percentage of macrophages, neutrophils (from 0.65% to 4.28% and 6.79% to 14.11%, respectively), and epithelial cells and a decrease in cytokines in induced sputum, followed by an increase in eNO concentration (20 +/- 11 to 35 +/- 19 ppb), which presented a significant reduction 24 and 72 hours after marathon (9 +/- 12 e 12 +/- 9 ppb, p < 0.05). We observed a decrease in the spirometry parameters in all time points assessed after the marathon (p < 0.05) as well as in cardiopulmonary capacity, evidenced by a reduction in VO2 and ventilation peaks (57 +/- 6 to 55 +/- 6 mL.min(-1).Kg(-1 )and 134 +/- 19 to 132 +/- 18 Lpm, respectively, p < 0.05). Finally, we observed a negative correlation between the decrease in forced expiratory volume and decrease in eNO 24 and 72 hours after marathon (r = -0.4, p = 0.05). Conclusion. Reduction in eNO bioavailability after marathon prevents the reduction in cardiopulmonary capacity induced by acute inflammatory pattern after marathon. (AU) | |
| FAPESP's process: | 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite |
| Grantee: | Manoel Carneiro de Oliveira Junior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/21501-0 - Role of genotypes, miocardial injury and inflammatory markers on cardiopulmonar changes induced by marathon race |
| Grantee: | Maria Fernanda Cury Boaventura |
| Support Opportunities: | Regular Research Grants |