Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

Author(s)

Francisqueti-Ferron, Fabiane Valentini ; Togneri Ferron, Artur Junio ; Garcia, Jessica Leite ; Vagula de Almeida Silva, Carol Cristina ; Costa, Mariane Rovero ; Gregolin, Cristina Schmitt ; Moreto, Fernando ; Ferreira, Ana Lucia A. ; Minatel, Igor Otavio ; Correa, Camila Renata

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 13, p. 14-pg., 2019-07-01.

Abstract

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders. (AU)

• FAPESP's process: 18/15294-3 - Influence of gamma-orizanol intervention on the prevention of cardiorreanal metabolic syndrome in obese rats: participation of protein carbonylation
• Grantee: Camila Renata Corrêa
• Support Opportunities: Regular Research Grants