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Influence of TLR4 receptors in behavioral and neurochemical alterations caused by intermittent fasting in C3H/HeJ mice

Grant number: 11/12255-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2011
Effective date (End): April 30, 2016
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Cristoforo Scavone
Grantee:Andrea Rodrigues Vasconcelos
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/03613-6 - Changes in NF-kB in glia and neuron induced by intermittent fasting in TLR4 KO mice, BE.EP.DR


Studies have shown that dietary energy restriction (DER) without malnutrition can increase resistance of neurons to excitotoxic stress and may ameliorate age-related deficits in cognitive function through hormetic mechanisms involving activation of adaptive cellular stress response pathways. Fundamental to the hormetic adaptive response is gene expression regulation. Although different stressors elicit unique signature responses, the comparison of prototypical hormetic inducers has highlighted the role played by a few transcription factors such as nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB), Forkhead box O (FOXO) and NFE2 related factor 2 (NRF2). NFKB plays a key role in regulating the immune response to infection and has also been implicated in processes of synaptic plasticity and memory. FOXO and NRF2 can enhance transcription of genes containing an antioxidant response element (ARE). Our data demonstrated that intermittent fasting can ameliorate cognitive deficits associated to LPS treatment, and suggest roles for TLR4 in this beneficial effect of DER. The aim of the present work is to investigate the influence of TLR4 receptors in the in behavioral and neurochemical alterations caused by intermittent fasting in C3H/HeJ mice. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
YSHII, LIDIA M.; DENADAI-SOUZA, ALEXANDRE; VASCONCELOS, ANDREA R.; AVELLAR, MARIA CHRISTINA W.; SCAVONE, CRISTOFORO. Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells. JOURNAL OF NEUROINFLAMMATION, v. 12, . (11/10303-5, 11/12255-8, 09/12375-3)
KINOSHITA, PAULA F.; YSHII, LIDIA M.; ORELLANA, ANA MARIA M.; PAIXAO, AMANDA G.; VASCONCELOS, ANDREA R.; LIMA, LARISSA DE SA; KAWAMOTO, ELISA M.; SCAVONE, CRISTOFORO. Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. SCIENTIFIC REPORTS, v. 7, . (11/22844-0, 11/10303-5, 14/05026-0, 16/07376-4, 11/21308-8, 11/12255-8, 11/04327-9)
VASCONCELOS, ANDREA R.; DA PAIXAO, AMANDA G.; KINOSHITA, PAULA F.; ORELLANA, ANA M.; SCAVONE, CRISTOFORO; KAWAMOTO, ELISA M.. Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain. Neuroscience, v. 465, p. 142-153, . (14/01435-3, 19/12974-6, 16/22996-9, 16/07376-4, 06/57729-9, 16/07427-8, 11/12255-8, 09/11915-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VASCONCELOS, Andrea Rodrigues. Influence of TLR4 and TLR2 in behavioral and biochemical effects induced by intermittent fasting in knockout mice.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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