Purinergic receptors in neurogenic processes

Author(s)

Ribeiro, D. E. ; Glaser, T. ; Oliveira-Giacomelli, A. ; Ulrich, H.

• Document type: Journal article
• Source: Brain Research Bulletin; v. 151, p. 9-pg., 2019-09-01.

Abstract

Neurogenesis is a process of generating functional neurons, which occurs during embryonic and adult stages in mammals. While neurogenesis during development phase is characterized by intensive proliferation activity in all regions of the brain to form the architecture and neural function of the nervous system, adult neurogenesis occurs with less intensity in two brain regions and is involved in the maintenance of neurogenic niches, local repair, memory and cognitive functions in the hippocampus. Taking such differences into account, the understanding of molecular mechanisms involved in cell differentiation in developmental stages and maintenance of the nervous system is an important research target. Although embryonic and adult neurogenesis presents several differences, signaling through purinergic receptors participates in this process throughout life. For instance, while embryonic neurogenesis involves P2X7 receptor down-regulation and calcium waves triggered by P2Y1 receptor stimulation, adult neurogenesis may be enhanced by increased activity of A(2A) and P2Y1 receptors and impaired by A(1), P2Y13 and P2X7 receptor stimulation. (AU)

• FAPESP's process: 15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision
• Grantee: Talita Glaser
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
• Grantee: Alexander Henning Ulrich
• Support Opportunities: Research Projects - Thematic Grants