Energy Trade-offs in Host Defense: Immunology Meets Physiology

Author(s)

Steiner, Alexandre A. ; Romanovsky, Andrej A.

• Document type: Journal article
• Source: TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 30, n. 12, p. 4-pg., 2019-12-01.

Abstract

Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers. (AU)

• FAPESP's process: 18/03418-0 - Hypothermia in Sepsis: causes and consequences
• Grantee: Alexandre Alarcon Steiner
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/03831-8 - Linking energy balance to systemic inflammation: role of leptin
• Grantee: Alexandre Alarcon Steiner
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/04921-1 - Arterial tonus in septic shock: a new facet to an old problem.
• Grantee: Alexandre Alarcon Steiner
• Support Opportunities: Regular Research Grants