Role of adiponectin and obesity in the rejection of allogeneic transplants

• Grant number: 12/23347-3
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2013
• Effective date (End): May 31, 2017
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Marina Burgos da Silva
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches, AP.TEM
• Associated scholarship(s): 15/14370-0 - The role of obesity and related intestinal microbiota in GVHD, BE.EP.DR

Abstract

Given the epidemic rates of obesity worldwide, it is of great importance to study the physiological and pathological effects consequent to this change. Studies show that excess fat has many harmful effects on human physiology and it is associated with multiple increased comorbidities in recent decades. Moreover, it is now known that in addition to modulating different systems related to energy metabolism, adipose tissue is also an important endocrine regulator. Among the bioactive products it produces, adiponectin, (APN) discovered almost 15 years ago, has received great attention.APN is a factor secreted primarily by adipose tissue and plays an important role in regulating energy metabolism and the immune system. Research indicates that it is capable of inhibiting the pro-inflammatory activation of several cells, such as monocytes, dendritic cells and lymphocytes. In parallel, its expression is inversely correlated with various pathologies of inflammatory nature as atherosclerosis and cardiovascular diseases.Although several researchers have focused on the role of this molecule in the cardiovascular system, little is known about its action on pathologies related to allogeneic reactivity and immune rejection. Thus, we propose to study through this work the role of obesity and, in particular, adiponectin in the process of organ rejection using an allogeneic murine skin transplant model and a graft-versus-host disease model. This study will clarify the effect of these components in immune activation and elucidate the modulatory mechanisms of adiponectin in the rejection process.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Marina Burgos da. Role of obesity in alogeneic transplant rejection.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.