Role of obesity in alogeneic transplant rejection.

Author(s)

Marina Burgos da Silva

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2017-05-18

Examining board members

Niels Olsen Saraiva Câmara; Regiane Aparecida Cavinato; Daniella Marcia Bahia Kerbauy; Fernanda Ortis; Nancy Starobinas

• Advisor: Niels Olsen Saraiva Câmara

Abstract

In addition to modulating energy metabolism, the adipose tissue is an endocrine regulator, producing factors such as adiponectin (APN), an adipokine little in obesity, with immunoregulatory properties. In this work we investigated the role of obesity and APN in skin transplant and graft-versus-host disease (GvHD) in high-fat diet induced obesity (Ob) and knockout (KO) mice for APN. In summary, Ob and APN KO receptors showed accelerated skin graft rejection, associated with Th1 and Th17 type inflammation. Obesity also led to worse GvHD, associated with increased inflammation in liver, lung, intestines along with liver and gut damage, while maintenance of the HF diet after transplantation partially prevented this damage. In vitro studies corroborated these results, showing greater dendritic and lymphocytic activation in conditions mimicking obesity. Thus, this study suggests that obesity and reduced APN lead to greater rejection of transplants further suggesting an important role of diet in this process. (AU)

• FAPESP's process: 12/23347-3 - Role of Adiponectin and Obesity in the Rejection of Allogeneic Transplants.
• Grantee: Marina Burgos da Silva
• Support Opportunities: Scholarships in Brazil - Doctorate