Current advances in bone tissue engineering concerning ceramic and bioglass scaffolds: A review

Author(s)

Ribas, Renata Guimardes ; Schatkoski, Vanessa Modelski ; do Amaral Montanheiro, Thais Larissa ; Canuto de Menezes, Beatriz Rossi ; Stegemann, Cristiane ; Gonsalves Leite, Douglas Marcel ; Thim, Gilmar Patrocinio

• Document type: Journal article
• Source: CERAMICS INTERNATIONAL; v. 45, n. 17, p. 11-pg., 2019-12-01.

Abstract

Life expectancy has been growing, and more people are developing bone diseases such as arthritis and osteoporosis. Degenerative pathologies, injuries, and trauma can damage the bone tissues, requiring treatments that facilitate its repair, replacement, or regeneration. In this context, many materials have been developed to match this demand. Bioglasses and ceramics are promising inorganic materials to produce scaffolds for bone regeneration due to their attractive properties, such as biocompatibility, osteoinduction, and osteoconduction, besides their similarity with bone composition. Although their established advantages, these materials present limitations such as inadequate mechanical properties and fast degradation rate. Research work has been widely carried out to develop bioglasses, silicate, and phosphate calcium ceramics scaffolds with appropriated properties to enlarge their applications in bioengineering. Different fabrication techniques have also been evaluated. Incorporating other materials or particles, such as polymers, oxides and metal particles into the scaffolds has shown beneficial effects in mechanical strength and bone production stimulation. In this review, we provide an overview concerning the recent advances in developing calcium phosphates, calcium silicates, bioglasses, and composites scaffolds for bone regeneration in medical and dental applications. (AU)

• FAPESP's process: 17/02846-5 - AgVO3/PMMA Nanocomposites: Effect of functionalization with acrilamide on mechanical and antimicrobial properties
• Grantee: Beatriz Rossi Canuto de Menezes Rodrigues
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/27079-7 - Reinforcement of a wollastonite cement (CaSiO3) by carbon nanotubes for biomedical or dental applications
• Grantee: Renata Guimarães Ribas
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
• Grantee: Thaís Larissa do Amaral Montanheiro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/12035-7 - Mechanical and antimicrobial properties of Ag/PMMA nanocomposite
• Grantee: Gilmar Patrocínio Thim
• Support Opportunities: Regular Research Grants